Patents Assigned to Hadasit Medical Research Services and Development
  • COMPLIANCE MEASUREMENT
    Publication number: 20210146101
    Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
    Type: Application
    Filed: January 25, 2021
    Publication date: May 20, 2021
    Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Ofer BARNEA, Omer DORON
  • Alpha-1 anti-trypsin for treating liver diseases
    Patent number: 10980866
    Abstract: Methods of treating liver diseases are provided. Accordingly there is provided a method of treating a liver disease selected from the group consisting of fatty liver disease and chronic liver rejection in a subject in need thereof, wherein said liver disease is not associated with genetic alpha-1 anti-trypsin (AAT) deficiency, the method comprising administering to the subject a therapeutically effective amount of AAT.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: April 20, 2021
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventor: Yaron Ilan
  • Formation of stable cartilage
    Patent number: 10940241
    Abstract: Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: March 9, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Hadasit Medical Research Services and Development Ltd.
    Inventors: Pamela Gehron Robey, Sergei Kuznetsov, Raphael Gorodetsky, Astar Hailu-Lazmi, Mitchell Shirvan, Joseph Featherall
  • Use of guaiacol for the prevention and treatment of glycogen storage disease
    Patent number: 10933031
    Abstract: The current invention is a method of preventing and treating certain diseases by preventing the synthesis and/or breakdown of glycogen by the administration of an agent, guaiacol. Diseases that can be prevented and treated by the administration of guaiacol include but are not limited to glycogen storage disease type IV (GSD-IV), adult polyglucosan body disease (APBD), and Lafora disease (LD). The invention also includes methods and tools for screening for agents that prevent and treat these diseases as well as basic research, specifically in the form of cells and cell lines that produce detectable polyglucosan.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: March 2, 2021
    Assignees: The Trustees of Columbia University in the City of New York, Hadasit Medical Research Services and Development Ltd., Ramot at Tel-Aviv University, Ltd.
    Inventors: Hasan Orhan Akman, Salvatore Dimauro, Or Kakhlon, Miguel Enrique Weil
  • Attenuated or inactivated pathogenic for treating urogenital cancer
    Patent number: 10918677
    Abstract: The present invention provides attenuated or inactivated pathogenic bacteria having anti-cancer properties, compositions comprising the bacteria, and use thereof for treating cancers of the urogenital system.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: February 16, 2021
    Assignees: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Ofer Mandelboim, Gilad Benjamin Bachrach, Chamutal Gur, Vladimir Yutkin
  • METHODS OF DISRUPTING A BIOFILM AND/OR PREVENTING FORMATION OF SAME
    Publication number: 20210015889
    Abstract: Methods of disrupting a biofilm and/or preventing formation of a biofilm are provided. Accordingly there is provided a method of reducing or preventing formation of a biofilm and/or disrupting a biofilm comprising contacting a biofilm-producing microorganism with a carbonic anhydrase inhibitor; a urease inhibitor; a Ca2+ ATPase inhibitor; a tlp activator; and/or a myo-inositol catabolism pathway activator. Also provided are articles of manufacture and methods of treating a medical condition in which disrupting a biofilm and/or preventing formation of same is beneficial and methods of predicting or increasing sensitivity to an anti-microbial agent.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 21, 2021
    Applicants: Yeda Research and Development Co. Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Ilana KOLODKIN-GAL, Alona KEREN-PAZ, Eitan KEREM, Gideon ZAMIR, Dror KOLODKIN-GAL, Malena COHEN-CYMBERKNOH
  • Supplementation of milk formulas with microvesicles isolated from milk
    Patent number: 10874114
    Abstract: Provided are microvesicles isolated from milk, compositions thereof and uses for the preparation of milk formulas. Further provided are microvesicles, including exosomes and/or fat globules which encapsulate various miRNA molecules and uses thereof, as exemplified by supplementing milk formulas.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: December 29, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Shimon Reif, Regina Golan
  • Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine
    Patent number: 10828308
    Abstract: Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 10, 2020
    Assignee: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Yaron Ilan, Doina Cosma Roman, Michael Hayden, Einat Amit-Romach
  • Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof
    Patent number: 10814018
    Abstract: The present invention provides isotopically labeled deoxy-glucose and derivatives thereof, methods of their preparation, ration, kits comprising them and uses thereof for spin hyperpolarized magnetic resonance imaging, utilized in the quantitative and qualitative diagnosis of states, conditions, diseases, or disorders in the body of a subject.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: October 27, 2020
    Assignee: HADASIT MEDICAL RESEARCH SERVICE & DEVELOPMENT LTD.
    Inventors: Moshe Gomori, Hyla Allouche-Arnon, Rachel Katz-Brull
  • Radiolabeled erlotinib analogs and uses thereof
    Patent number: 10710968
    Abstract: Radiolabeled compounds which are erlotinib analogs that feature a radioactive halogen and processes of preparing same are disclosed. Uses of these radiolabeled compounds in radioimaging, for identifying and monitoring a level, distribution and/or mutational status of deregulated EGFR, and/or in radiotherapy, are also disclosed.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: July 14, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Eyal Yosef Mishani, Ofer Shamni, Galith Rachel Abourbeh-Gofrit
  • Devices and methods for percutaneous endoscopic gastrostomy and other ostomy procedures
    Patent number: 10695270
    Abstract: Ostomy tubes, particularly gastrostomy tubes, with improved retention means are provided. More specifically, retention structures, such as bolsters, for gastrostomy tubes are provided, configured to removably assemble to one end of a gastrostomy tube to facilitate replacement and removal of the tube. The retention structures provided herein may comprise one or more removably assembled retention elements. Further provided are gastrostomy tubes comprising such retention structures, and methods for percutaneous endoscopic gastrostomy utilizing same.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 30, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventor: Ishay Benuri-Silbiger
  • FORMATION OF STABLE CARTILAGE
    Publication number: 20200171215
    Abstract: Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.
    Type: Application
    Filed: May 31, 2018
    Publication date: June 4, 2020
    Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Pamela Gehron Robey, Sergei Kuznetsov, Raphael Gorodetsky, Astar Hailu-Lazmi, Mitchell Shirvan, Joseph Featherall
  • DETECTING TISSUE-SPECIFIC DNA
    Publication number: 20200165671
    Abstract: A method of determining the methylation status of at least one methylation site of a double-stranded DNA molecule is disclosed. The method comprises analyzing the methylation status of both the forward strand and the reverse strand of the DNA molecule.
    Type: Application
    Filed: July 13, 2018
    Publication date: May 28, 2020
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventors: Yuval DOR, Ruth SHEMER, Benjamin GLASER, Judith MAGENHEIM
  • Extracts of edible fungi enriched in vitamin D and compostions thereof and their use in the treatment of immune-related disorders
    Patent number: 10617697
    Abstract: A vitamin D2-enriched biomass of an edible fungus, extracts and compositions thereof are provided, for use in delaying onset of, treating, ameliorating or protecting from an immune-related or inflammatory related disease, disorder or condition, wherein the level of vitamin D2 in said biomass is at least 80 IU/gr.
    Type: Grant
    Filed: January 17, 2016
    Date of Patent: April 14, 2020
    Assignees: GAVISH-GALILEE BIO APPLICATIONS, LTD., HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD
    Inventors: Dan Levanon, Yaron Ilan, Ofer Danai
  • PAR1 and PAR2 c-tail peptides and peptide mimetics
    Patent number: 10611798
    Abstract: The present invention concerns isolated PAR1 cytoplasmic tail (c-tail) peptides and isolated PAR2 cytoplasmic tail (c-tail) peptides, as well as compositions comprising these peptides, uses thereof and methods of treating various diseases, in particular cancer.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: April 7, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventor: Rachel Bar-Shavit
  • Methods for treating or reducing liver diseases by administering oral composition comprising TNF receptor fusion proteins
    Patent number: 10611821
    Abstract: This application describes a method of delivering a TNF antagonist molecule, in a biologically active form, to a subject in need thereof, the method comprising, orally or mucosally administering to the subject a therapeutically effective amount of a TNF antagonist molecule. This application further describes a method of treating, preventing or reducing liver diseases, the method comprising, administering to the subject a therapeutically effective amount of a TNF antagonist molecule.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: April 7, 2020
    Assignee: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.
    Inventor: Yaron Ilan
  • INTRACRANIAL VOLUME ADAPTOR FOR CEREBRAL BLOOD FLOW
    Publication number: 20200061355
    Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
    Type: Application
    Filed: November 16, 2017
    Publication date: February 27, 2020
    Applicants: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd., Hadasit Medical Research Services and Development Ltd.
    Inventors: Ofer BARNEA, Omer DORON
  • PHOTORECEPTOR CELLS FOR THE TREATMENT OF RETINAL DISEASES
    Publication number: 20200032204
    Abstract: A method of generating photoreceptor cells is disclosed. Cell populations comprising photoreceptor cells and uses thereof are also disclosed.
    Type: Application
    Filed: February 8, 2018
    Publication date: January 30, 2020
    Applicant: Hadasit Medical Research Services and Development Ltd.
    Inventors: Benjamin E. Reubinoff, Masha Gorshtein, Hanita Khaner, Alex Obolensky, Eyal Banin
  • Formulations of 6-mercaptopurine
    Patent number: 10525009
    Abstract: The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: January 7, 2020
    Assignee: Hadasit Medical Research Services and Development Ltd.
    Inventors: Itzhak E. Lerner, Moshe Flashner-Barak, Erwin v Achthoven, Hans Keegstra, Ruud Smit
  • INHIBITORS OF NEUROLIGIN 4-NEUREXIN 1-BETA PROTEIN-PROTEIN INTERACTION FOR TREATMENT OF LIVER DISORDERS
    Publication number: 20190389948
    Abstract: Method for treating, attenuating and/or preventing progression of a liver disorder in a subject, the method including administering a therapeutically effective amount of an agent capable of interfering with, inhibiting and/or preventing neuroligin 4 (NLGn4)-Neurexin 1-beta (Nrx1b) protein-protein interaction; and compositions including the agent.
    Type: Application
    Filed: May 9, 2019
    Publication date: December 26, 2019
    Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
    Inventor: Rifaat SAFADI