Abstract: The invention provides a pharmaceutical composition for preventing restens by the inhibition of vascular smooth muscle cell proliferation, comprising a compound of formula I: ##STR1## wherein: n=1 or 2 R.sub.1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy;R.sub.2 is a member of the group consisting of hydroxy, acetoxy, and lower alkoxy, andR.sub.3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonylas active ingredient therein, and the physiologically acceptable salts thereof, in combination with a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
December 9, 1996
Date of Patent:
April 6, 1999
Assignees:
Hadasit Medical Research Services & Development Co., Inc., Agricultural Organization Ministry of Agriculture State of Israel
Inventors:
Arnon Nagler, Shimon Slavin, Israel Vlodavsky, Mark Pines