Patents Assigned to Hallux, Inc.
  • Publication number: 20220313627
    Abstract: Compositions and methods are presented that provide substantially improved physical and pharmacological parameters for subungually administrable formulations. Most beneficially, the compositions presented herein have a viscosity and film-forming capacity that retain the liquid formulation in sufficient quantities and that help penetrate the polysaccharide matrix commonly associated with onychomycosis. In especially preferred aspects, the carrier is formulated to have a high concentration of the active pharmaceutically active agent (API), to allow migration of the formulation within the subungual space, and to reduce systemic absorption while promoting diffusion of the API into the nail plate at or above minimum inhibitory concentration into a larger treatment space.
    Type: Application
    Filed: June 14, 2022
    Publication date: October 6, 2022
    Applicant: Hallux Inc.
    Inventors: Christopher Ronald Agee, Robert L. Orr, Thomas Mark Tremblay
  • Patent number: 11400061
    Abstract: Compositions and methods are presented that provide substantially improved physical and pharmacological parameters for subungually administrable formulations. Most beneficially, the compositions presented herein have a viscosity and film-forming capacity that retain the liquid formulation in sufficient quantities and that help penetrate the polysaccharide matrix commonly associated with onychomycosis. In especially preferred aspects, the carrier is formulated to have a high concentration of the active pharmaceutically active agent (API), to allow migration of the formulation within the subungual space, and to reduce systemic absorption while promoting diffusion of the API into the nail plate at or above minimum inhibitory concentration into a larger treatment space.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: August 2, 2022
    Assignee: HALLUX INC.
    Inventors: Christopher Ronald Agee, Robert L. Orr, Thomas Mark Tremblay
  • Publication number: 20210401778
    Abstract: Compositions and methods are presented that provide substantially improved physical and pharmacological parameters for subungually administrable formulations. Most beneficially, the compositions presented herein have a viscosity and film-forming capacity that retain the liquid formulation in sufficient quantities and that help penetrate the polysaccharide matrix commonly associated with onychomycosis. In especially preferred aspects, the carrier is formulated to have a high concentration of the active pharmaceutically active agent (API), to allow migration of the formulation within the subungual space, and to reduce systemic absorption while promoting diffusion of the API into the nail plate at or above minimum inhibitory concentration into a larger treatment space.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Applicant: Hallux Inc.
    Inventors: Robert L. Orr, Christopher Ronald Agee, Thomas Mark Tremblay
  • Patent number: 10456568
    Abstract: Methods for the subungual treatment of diseases or disorders of the nail unit including infections, especially fungal infections, and nail psoriasis involving the toenails and fingernails are described. The methods provide a technique for placement of a drug-containing composition subungually with reduced risk of hematoma formation and improved patient comfort.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 29, 2019
    Assignee: HALLUX, INC.
    Inventors: Jay E. Birnbaum, Bruce Lerman
  • Patent number: 9498612
    Abstract: Methods for the subungual treatment of diseases or disorders of the nail unit including infections, especially fungal infections, and nail psoriasis involving the toenails and fingernails are described. The methods provide a technique for placement of a drug-containing composition subungually with reduced risk of hematoma formation and improved patient comfort.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 22, 2016
    Assignee: Hallux, Inc.
    Inventors: Jay E. Birnbaum, Bruce Lerman
  • Patent number: 9446009
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 20, 2016
    Assignee: Hallux, Inc.
    Inventors: Frank Kochinke, Corinne Bright
  • Patent number: 9375558
    Abstract: Methods for the subungual treatment of diseases or disorders of the nail unit including infections, especially fungal infections, and nail psoriasis involving the toenails and fingernails are described. The methods provide a technique for placement of a drug-containing composition subungually with reduced risk of hematoma formation and improved patient comfort.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: June 28, 2016
    Assignee: Hallux, Inc.
    Inventors: Jay E. Birnbaum, Bruce Lerman
  • Publication number: 20140322293
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicant: Hallux, Inc.
    Inventors: Frank Kochinke, Corinne Bright
  • Patent number: 8747820
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 10, 2014
    Assignee: Hallux, Inc.
    Inventors: Frank Kochinke, Corinne Bright
  • Publication number: 20140050772
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Application
    Filed: October 23, 2013
    Publication date: February 20, 2014
    Applicant: Hallux. Inc.
    Inventors: Frank Kochinke, Corrine Bright
  • Patent number: 8591870
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: November 26, 2013
    Assignee: Hallux, Inc.
    Inventors: Frank Kochinke, Corinne Bright
  • Publication number: 20130122097
    Abstract: Described here are various compositions for the delivery active agents, e.g., antifungal agents. The compositions may be beneficial due to the particular release kinetics associated with them. Various locations and methods for placement of the compositions into the tissues of the nail unit, as well as tissues surrounding the nail unit are also described.
    Type: Application
    Filed: December 22, 2010
    Publication date: May 16, 2013
    Applicant: HALLUX, INC.
    Inventors: Corinne Bright, Jinping Wan, Martin Babler, Ayse Zamboglu
  • Patent number: 8404751
    Abstract: Onychomycosis is a fungal infection of the nail bed and is difficult to treat topically because penetration of the nail plate is difficult, and systemic antifungal treatments are prone to side effects and drug interactions. The present invention treats onychomycosis by applying an antifungal composition to the nail bed directly using a solid, semi-solid, or flowable carrier. The carrier can be in the form of a semi-solid into which the user digs and scrapes the nail, a solid carrier can be inserted directly under the nail in contact with the nail bed, or a flowable composition can be injected in contact with the nail bed.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: March 26, 2013
    Assignee: Hallux, Inc.
    Inventors: Jay E. Birnbaum, Keith A. Johnson
  • Patent number: 8354095
    Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include greater than 30% by weight of the active agent, and may be formulated as solutions, solids, semisolids, microparticles, or crystals. Methods related to the implantation and use of the biodegradable drug delivery systems for treating nail unit conditions are also described.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 15, 2013
    Assignee: Hallux, Inc.
    Inventors: Frank M. Kochinke, Corinne Bright