Patents Assigned to Hamamatsu University School of Medicine
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Patent number: 10352527Abstract: Provided is a luminous, apparatus such as a display, having a function of preventing attraction of insects. A display apparatus 1 has a light emission surface 1 whose peripheral edge region is at least partially formed as a low-attraction region which is less capable of attracting bugs, wherein the low-attraction region is composed of an optical property gradient region whose at least one optical property gradually changes in a direction from an inward side to an outward side of the light emission surface.Type: GrantFiled: September 18, 2015Date of Patent: July 16, 2019Assignee: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Yoshihiro Uozu, Takahiko Hariyama, Mantaro Hironaka
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Publication number: 20190209012Abstract: A biological measurement device includes a probe including a contact surface that includes a plurality of light input portions that input light to a measurement target part and a plurality of light receiving portions that receive measurement light output from the measurement target part, the contact surface being pressed against the measurement target part, and a calculation unit that calculates internal information on the basis of a result of detecting the measurement light obtained for each combination of the light input portion and the light receiving portion, wherein the plurality of light input portions and the plurality of light receiving portions constitute lattices having an interval d in a first direction and a second direction orthogonal to each other on the contact surface.Type: ApplicationFiled: September 4, 2017Publication date: July 11, 2019Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Kenji YOSHIMOTO, Yukio UEDA, Etsuko OHMAE, Tetsuya MIMURA, Nobuko YOSHIZAWA, Hatsuko NASU, Hiroyuki OGURA, Harumi SAKAHARA
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Publication number: 20190070608Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.Type: ApplicationFiled: September 5, 2018Publication date: March 7, 2019Applicants: HAMAMATSU PHOTONICS K.K., NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Hirotoshi KIKUCHI, Shigetoshi OKAZAKI, Hidenao YAMADA, Yusuke OZAKI, Amane HIROTSU, Daisuke YAMASHITA
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Patent number: 10180387Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.Type: GrantFiled: July 23, 2015Date of Patent: January 15, 2019Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.Inventors: Yusuke Ozaki, Hidenao Iwai, Hiroyuki Konno, Hirotoshi Kikuchi, Toyohiko Yamauchi
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Patent number: 10143379Abstract: A fluorescence detection device comprises: a plurality of light sources that apply an excitation light from an outside of a living body toward fluorescent dye previously injected into the living body; and a plurality of detectors that detect fluorescence emitted from the fluorescent dye by the excitation light, and output the detected fluorescence as an electric signal. The plurality of light sources and the plurality of detectors are arranged in at least one line. At least one detector is placed between two light sources, and at least one light source is placed between two detectors.Type: GrantFiled: February 18, 2013Date of Patent: December 4, 2018Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.Inventors: Naoki Unno, Yoshimasa Hattori, Mitsuharu Miwa
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Patent number: 10051851Abstract: By plates (31, 32) having different colors, an edge is formed in the vertical direction along the boundary between the plates (31, 32). Further, as materials of the plates (31, 32), a material which primarily transmits ultraviolet light having a wavelength of about 370 nm and a material which primarily transmits green light having a wavelength of about 520 nm are used. This constitution makes an attraction device (10) capable of attracting insect pests more efficiently as compared to a case where a light source such as a mercury lamp which emits a large amount of light having a wavelength of 300 to 600 nm or an LED which emits a large amount of light having a relatively short wavelength is used.Type: GrantFiled: September 20, 2012Date of Patent: August 21, 2018Assignee: HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Takahiko Hariyama, Mantaro Hironaka
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Patent number: 9943333Abstract: The present invention relates to an agent for activating mammalian sperm and a method for activating sperm by use of the activating agent. More specifically, the present invention relates to a sperm activating agent containing endo-?-galactosidase and/or FGF, which accelerate motility of mammalian sperm, for use in in-vitro fertilization and artificial insemination by husband and a sperm activating method by adding endo-?-galactosidase and/or FGF.Type: GrantFiled: September 19, 2013Date of Patent: April 17, 2018Assignees: NATIONAL UNIVERSITY CORPORATION, HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Kazuhiro Sugihara, Michiko Fukuda
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Publication number: 20170212033Abstract: The identification apparatus includes a quantitative phase image acquisition unit, a feature quantity extraction unit, a learning unit, a storage unit, and an identification unit. The feature quantity extraction unit extracts a feature quantity of a quantitative phase image of a cell. The learning unit performs machine learning for a quantitative phase image of a known cell of which a type is known based on the feature quantity extracted by the extraction unit. The storage unit stores a result of the machine learning by the learning unit. The identification unit determines, based on the feature quantity extracted by the extraction unit for the quantitative phase image of an unknown cell of which a type is unknown, the type of the unknown cell using the learning result stored by the storage unit.Type: ApplicationFiled: July 23, 2015Publication date: July 27, 2017Applicants: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.Inventors: Yusuke OZAKI, Hidenao IWAI, Hiroyuki KONNO, Hirotoshi KIKUCHI, Toyohiko YAMAUCHI
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Patent number: 9676820Abstract: A method is provided for inhibiting proliferation of a high LIX1L-expressing tumor cell, in which the expression or function of a LIX1L gene with respect to a tumor cell highly expressing the LIX1L gene is inhibited.Type: GrantFiled: April 2, 2014Date of Patent: June 13, 2017Assignee: National University Corporation Hamamatsu University School of MedicineInventors: Satoki Nakamura, Haruhiko Sugimura
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Patent number: 9610359Abstract: Disclosed are conjugates comprising the annexin 1-binding peptide IFLLWQR covalently linked to a therapeutic or detectable agent. Also disclosed are compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell.Type: GrantFiled: December 23, 2010Date of Patent: April 4, 2017Assignees: Burnham Institute for Medical Research, Hamamatsu University School of MedicineInventors: Michiko Fukuda, Kazuhiro Sugihara, Naohira Kanayama
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Patent number: 9597031Abstract: The present invention has an object to measure lymphatic pressure with more safety and ease at lower cost. To achieve this, a lymphatic pressure-measuring system 1 includes: a manchette 11 fitted on a vital observation portion; a measurement unit 13 that measures and outputs pressure of the manchette 11; an infrared camera 21 that detects fluorescence emitted from fluorescent dye previously injected into a lymph vessel in the vital observation portion; and an image processing device 22 that generates and displays an image showing a position of the fluorescent dye in the lymph vessel based on a detection result of the infrared camera 21. The infrared camera 21 repeats the detection while the pressure of the manchette 11 decreases from first pressure to block a lymph flow in the vital observation portion to second pressure at restart of the lymph flow. The measurement unit 13 repeats the measurement during the period.Type: GrantFiled: March 16, 2015Date of Patent: March 21, 2017Assignee: National University Corporation Hamamatsu University School of MedicineInventor: Naoki Unno
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Patent number: 9538947Abstract: Method, system and device for assisting diagnosis of autism which enable assistance of early detection and early definite diagnosis of autism (especially in infants) based on objective evaluation, using a conventionally suggested “eye-gaze detection technique”. The method for assisting diagnosis of autism of a subject uses an eye-gaze detecting unit, the unit having at least an imaging camera portion. The method includes displaying, at the position in front of the subject along the direction of the eye gaze of the subject, an illusionary image contained in a plane of an illusion-causing image on a displaying device. The eye-gaze position information of the subject looking at the plane is detected, and the eye-gaze position information of the subject is input into an eye-gaze position information storage portion The eye-gaze positions of the subject can be evaluated using a algorithm for assisting diagnosis of autism.Type: GrantFiled: September 4, 2012Date of Patent: January 10, 2017Assignee: National University Corporation Hamamatsu University School of MedicineInventors: Norio Mori, Katsuaki Suzuki, Kenji Tsuchiya, Chie Shimmura, Hirohisa Sakurai, Keijyu Tokutani
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Patent number: 9448234Abstract: A method for diagnosing a risk for preterm delivery or miscarriage in a pregnant woman and preventing preterm delivery or miscarriage in the pregnant woman who has been determined to have the risk is provided. The method includes measuring plasminogen activator inhibitor-1 activity or level in plasma isolated from a pregnant woman. The method also includes determining that the pregnant woman has a risk for preterm delivery or miscarriage when the activity or the level is lower than that in the plasma of a normal pregnant woman. The method also includes administering plasminogen activator inhibitor-1 to the pregnant woman who has been determined to have the risk. A kit for the diagnosis of the degree of risk for preterm delivery or miscarriage also is provided. A pharmaceutical composition for the prevention of preterm delivery or miscarriage, comprising plasminogen activator inhibitor-1, also is provided.Type: GrantFiled: November 15, 2012Date of Patent: September 20, 2016Assignee: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Naohiro Kanayama, Kazuo Umemura, Takayuki Iwaki, Tetsumei Urano, Kotomi Ikuma
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Patent number: 9433352Abstract: An accurate measurement can be made of the light absorbance of deep layer tissue such as in a human body or a fruit. The thickness of fat is computed. A first specific distance and a second specific distance corresponding to the computed fat thickness are computed based a predetermined relationship between the fat thickness, the first specific distance, and measurement sensitivity of a surface layer and measurement sensitivity of a deep layer when light is received at a position the first specific distance away from a light emitting means. A third specific distance and a fourth specific distance are computed corresponding to the computed fat thickness based on a predetermined relationship between the fat thickness, the third specific distance and a measurement sensitivity of an intervening layer and a measurement sensitivity of the deep layer when light is received at a position the third specific distance away from the light emitting means.Type: GrantFiled: February 23, 2012Date of Patent: September 6, 2016Assignees: National University Corporation Shizuoka University, National University Corporation Hamamatsu University School of MedicineInventors: Masatsugu Niwayama, Naohiro Kanayama, Kazunao Suzuki
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Patent number: 9393224Abstract: An object of the present invention is to provide a drug that contains a compound for inhibiting neutral lipid accumulation in cardiovascular tissue or cells and has an excellent prophylactic or therapeutic effect on cardiovascular complications of diabetes. The present invention relates to a prophylactic and/or therapeutic agent for cardiovascular complications of diabetes, the agent containing a compound (preferably a medium-chain fatty acid and/or a medium-chain triglyceride) for inhibiting neutral lipid accumulation.Type: GrantFiled: August 27, 2012Date of Patent: July 19, 2016Assignees: OSAKA UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, KOWA COMPANY, LTD.Inventors: Ken-ichi Hirano, Yoko Yasui, Yoshihiko Ikeda, Mitsutoshi Setou, Nobuhiro Zaima
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Patent number: 9297811Abstract: Disclosed is the construction of a system capable of quickly and easily identifying patients having a risk for worsening inflammatory digestive tract disease by identifying a causal factor for the worsening of the inflammatory digestive tract disease. Specifically disclosed is a method for detecting oral bacteria that cause worsening of inflammatory digestive tract disease and/or a screening that targets high risk for worsening of inflammatory digestive tract disease and/or determining the risk for worsening of the inflammatory digestive tract disease by PA not being detected and/or CBP being detected, inclusive of the detection of PA, which is an oral bacteria protein antigen, and/or CBP, which is collagen binding protein, in samples. Also disclosed are a detection reagent and kit used for this method.Type: GrantFiled: March 10, 2011Date of Patent: March 29, 2016Assignees: National University Corporation Hamamatsu University School of Medicine, Osaka UniversityInventors: Kazuo Umemura, Kazuya Hokamura, Kazuhiko Nakano, Takashi Ooshima, Ryota Nomura, Koichiro Wada
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Patent number: 9284623Abstract: The present invention enables simple production of osmium tetroxide having comparable performance to that sold in reagents from a solution containing osmium. The present invention relates to a method for producing osmium tetroxide solution, the method comprising a step for using ozone or a similar oxidizing gas to oxidize a solution containing osmium and produce osmium tetroxide gas and a step for introducing the resulting osmium tetroxide gas into a recovery solution; the present invention further relates to a production apparatus therefor.Type: GrantFiled: May 30, 2012Date of Patent: March 15, 2016Assignee: National University Corporation Hamamatsu University School of MedicineInventors: Kazushige Suzuki, Yoshinori Muranaka
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Publication number: 20150309053Abstract: A novel test method for testing for the presence or absence of a predisposition to autistic spectrum disorder or the presence or absence of development of autistic spectrum disorder is provided. The test method includes a test step of determining an amount of at least one of the fatty acid binding proteins FABP3, FABP4, FABP5, and FABP7 in a sample prepared from the living body of a human or determining an expression level of at least one of the FABP3, FABP4, FABP5, and FABP7 genes in the sample.Type: ApplicationFiled: October 23, 2013Publication date: October 29, 2015Applicants: RIKEN, NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINEInventors: Takeo Yoshikawa, Motoko Maekawa, Norio Mori, Hideo Matsuzaki, Kazuhiko Nakamura
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Publication number: 20150245852Abstract: The present invention relates to an agent for activating mammalian sperm and a method for activating sperm by use of the activating agent. More specifically, the present invention relates to a sperm activating agent containing endo-?-galactosidase and/or FGF, which accelerate motility of mammalian sperm, for use in in-vitro fertilization and artificial insemination by husband and a sperm activating method by adding endo-?-galactosidase and/or FGF.Type: ApplicationFiled: September 19, 2013Publication date: September 3, 2015Applicant: National University Corporation Hamamatsu University School of MedicineInventors: Kazuhiro Sugihara, Michiko Fukuda
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Publication number: 20150238134Abstract: The present invention has an object to measure lymphatic pressure with more safety and ease at lower cost. To achieve this, a lymphatic pressure-measuring system 1 includes: a manchette 11 fitted on a vital observation portion; a measurement unit 13 that measures and outputs pressure of the manchette 11; an infrared camera 21 that detects fluorescence emitted from fluorescent dye previously injected into a lymph vessel in the vital observation portion; and an image processing device 22 that generates and displays an image showing a position of the fluorescent dye in the lymph vessel based on a detection result of the infrared camera 21. The infrared camera 21 repeats the detection while the pressure of the manchette 11 decreases from first pressure to block a lymph flow in the vital observation portion to second pressure at restart of the lymph flow. The measurement unit 13 repeats the measurement during the period.Type: ApplicationFiled: March 16, 2015Publication date: August 27, 2015Applicants: National University Corporation Hamamatsu University School of Medicine, Hamamatsu Photonics K.K.Inventor: Naoki UNNO