Abstract: A new intermediate for synthesizing 1-substituted-4-[phenyl(propanoyl)amino]piperidine-4-carbonitrile derivatives is laid open. Specifically set out is a method for use of this intermediate in the preparation of remifentanil. The enclosed shorter process offers a greater yield of products with higher purity as compared to methods reported in the prior art.
Type:
Grant
Filed:
October 25, 2019
Date of Patent:
November 24, 2020
Assignee:
HAMELN PHARMA GMBH
Inventors:
Pavol Valachovic, Janka Králová, L'ubo{hacek over (s)} Slí{hacek over (z)}ik, Norbert Varga