Abstract: A new intermediate for synthesizing 1-substituted-4-[phenyl(propanoyl)amino]piperidine-4-carbonitrile derivatives is laid open. Specifically set out is a method for use of this intermediate in the preparation of remifentanil. The enclosed shorter process offers a greater yield of products with higher purity as compared to methods reported in the prior art.
Type:
Application
Filed:
October 25, 2019
Publication date:
April 30, 2020
Applicant:
Hameln Pharma Plus GmbH
Inventors:
Pavol Valachovic, Janka Králová, Lubos Slízik, Norbert Varga
Abstract: The invention relates to the production of zinc trisodium pentetic acid (Zn-DTPA) and to new crystalline forms of said salt.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
September 20, 2016
Assignee:
Hameln Pharma Plus GmbH
Inventors:
Christian Schickaneder, Vendel Smahovský, Pavol Valachovic, Mathias Dewald, Pavel Hradil, Janka Králová, Radek Melnický, Petr Slézar, Ivan Kakalik