Patents Assigned to Hampton University
-
Patent number: 11672797Abstract: The present invention relates to methods of treating or inhibiting keloids in a subject with hypoxia-inducible factor-1 (HIF-1) inhibiting compounds, methods of screening or identifying compounds to induce cell death in keloids, and methods of inducing cell death in keloids.Type: GrantFiled: May 8, 2020Date of Patent: June 13, 2023Assignee: Hampton UniversityInventors: Joanne Chan, Jessica L. Richert
-
Publication number: 20230010671Abstract: The present application provides compositions and methods for preparing and using “heavy” nucleotide derivatives of thymidine or uridine by replacing the oxygen atom attached to one or more of positions with non-radioactive oxygen-18 (18O), administering it to a subject to target a tumor including incorporation into tumor cell DNA, and then treating the tumor with proton beam therapy to transmutate the 18O to 18F, resulting in a break of the new fluorine-phosphorous bond. This chemical event destabilizes ribose-phosphate DNA back-bone and base pairing thus produce single- and double strand breaks, clusters lesions that can lead to irreparable DNA damage and enhanced tumor cell killing. The atomic, chemical, and physical aspects result in the use of lower radiation doses and significantly alter acute and late morbidity of radiotherapy. Heavy thymidine and heavy uridine derivatives labeled with 18O have been made and tested.Type: ApplicationFiled: June 27, 2022Publication date: January 12, 2023Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, HAMPTON UNIVERSITYInventors: Tyvin A. RICH, Dongfeng PAN, Mahendra D. CHORDIA
-
Patent number: 11396523Abstract: The present application provides compositions and methods for preparing and using “heavy” nucleotide derivatives of thymidine or uridine by replacing the oxygen atom attached to one or more of positions with non-radioactive oxygen-18 (18O), administering it to a subject to target a tumor including incorporation into tumor cell DNA, and then treating the tumor with proton beam therapy to transmutate the 18O to 18F, resulting in a break of the new fluorine-phosphorous bond. This chemical event destabilizes ribose-phosphate DNA back-bone and base pairing thus produce single- and double strand breaks, clusters lesions that can lead to irreparable DNA damage and enhanced tumor cell killing. The atomic, chemical, and physical aspects result in the use of lower radiation doses and significantly alter acute and late morbidity of radiotherapy. Heavy thymidine and heavy uridine derivatives labeled with 18O have been made and tested.Type: GrantFiled: June 22, 2018Date of Patent: July 26, 2022Assignees: University of Virginia Patent Foundation, Hampton UniversityInventors: Tyvin A. Rich, Dongfeng Pan, Mahendra D. Chordia
-
Patent number: 10556872Abstract: The present disclosure provides for methods of treating cancer in a subject. In certain embodiments, the method comprises administering a therapeutically effective amount of an inhibitor of fatty acid synthase, or a pharmaceutically acceptable salt or prodrug thereof.Type: GrantFiled: March 19, 2018Date of Patent: February 11, 2020Assignee: Hampton UniversityInventors: Vivek Kaushik, Anandkrishnan Iyer, Neelam Azad
-
Opposed view and dual head detector apparatus for diagnosis and biopsy with image processing methods
Patent number: 9844355Abstract: The invention relates generally to biopsy needle guidance which employs an x-ray/gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.Type: GrantFiled: July 23, 2014Date of Patent: December 19, 2017Assignee: HAMPTON UNIVERSITYInventors: Cynthia Keppel, Douglas Kieper -
Patent number: 9351691Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.Type: GrantFiled: April 14, 2015Date of Patent: May 31, 2016Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Paul Gueye, Christopher Sinesi
-
Patent number: 9211422Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less than 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.Type: GrantFiled: April 16, 2014Date of Patent: December 15, 2015Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Vahagn R. Nazaryan
-
Patent number: 9119961Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: GrantFiled: November 12, 2014Date of Patent: September 1, 2015Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Richard A. Britten, Vahagn R. Nazaryan
-
Publication number: 20150216491Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.Type: ApplicationFiled: April 14, 2015Publication date: August 6, 2015Applicant: HAMPTON UNIVERSITYInventors: Cynthia E. KEPPEL, Paul Gueye, Christopher Sinesi
-
Patent number: 9028390Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostics, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.Type: GrantFiled: July 18, 2013Date of Patent: May 12, 2015Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Paul Gueye, Christopher Sinesi
-
Publication number: 20150073200Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: ApplicationFiled: November 12, 2014Publication date: March 12, 2015Applicant: Hampton UniversityInventors: Cynthia E. KEPPEL, Richard A. BRITTEN, Vahagn R. NAZARYAN
-
Patent number: 8916842Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: GrantFiled: July 30, 2014Date of Patent: December 23, 2014Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Richard A. Britten, Vahagn R. Nazaryan
-
Publication number: 20140336442Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: ApplicationFiled: July 30, 2014Publication date: November 13, 2014Applicant: Hampton UniversityInventors: Cynthia E. KEPPEL, Richard A. BRITTEN, Vahagn R. NAZARYAN
-
OPPOSED VIEW AND DUAL HEAD DETECTOR APPARATUS FOR DIAGNOSIS AND BIOPSY WITH IMAGE PROCESSING METHODS
Publication number: 20140334603Abstract: The invention relates generally to biopsy needle guidance which employs an x-ray/gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.Type: ApplicationFiled: July 23, 2014Publication date: November 13, 2014Applicant: HAMPTON UNIVERSITYInventors: Cynthia KEPPEL, Douglas KIEPER -
Opposed view and dual head detector apparatus for diagnosis and biopsy with image processing methods
Patent number: 8855748Abstract: The invention relates generally to biopsy needle guidance which employs an x-ray/gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.Type: GrantFiled: October 9, 2012Date of Patent: October 7, 2014Assignee: Hampton UniversityInventors: Cynthia Keppel, Douglas Kieper -
Patent number: 8829476Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: GrantFiled: April 16, 2014Date of Patent: September 9, 2014Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Richard A. Britten, Vahagn R. Nazaryan
-
Publication number: 20140228616Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less then 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicant: HAMPTON UNIVERSITYInventors: Cynthia E. KEPPEL, Vahagn R. NAZARYAN
-
Publication number: 20140225010Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicant: HAMPTON UNIVERSITYInventors: Cynthia E. KEPPEL, Richard A. BRITTEN, Vahagn R. NAZARYAN
-
Patent number: 8742377Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.Type: GrantFiled: December 18, 2013Date of Patent: June 3, 2014Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Richard A. Britten, Vahagn R. Nazaryan
-
Patent number: 8734313Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less then 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.Type: GrantFiled: October 3, 2007Date of Patent: May 27, 2014Assignee: Hampton UniversityInventors: Cynthia E. Keppel, Vahagn R. Nazaryan