Patents Assigned to Hangzhou ACEA Pharmaceutical Research Co., Ltd.
  • Patent number: 11498922
    Abstract: The present invention relates to methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 15, 2022
    Assignees: ACEA Therapeutics, Inc., Hangzhou ACEA Pharmaceutical Research Co., Ltd., Zhejiang ACEA Pharmaceuticals Co., Ltd.
    Inventors: Long Mao, Jia Liu, Yile Chen, Yuning Hua, Kongen Dai, Yimei Bao, Bojie Weng, Xi-aopeng Mo, Jian Wu, Xiao Xu, Wanhong Xu, Xiaobo Wang
  • Publication number: 20210309642
    Abstract: The invention relates to solid forms of certain N-(pyrimidinyloxy)acrylamide derivatives that are useful in the treatment of proliferation and immunological disorders and other diseases related to the dysregulation of kinases including EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK. The invention provides methods of making these materials and their salts and polymorphs, and intermediates for preparing these materials, as well as pharmaceutical compositions comprising these materials. The solid forms and pharmaceutical compositions comprising them are useful to treat conditions including a proliferation disorder, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye, rheumatoid arthritis, or lupus.
    Type: Application
    Filed: August 9, 2018
    Publication date: October 7, 2021
    Applicants: ACEA Therapeutics, Inc., HANGZHOU ACEA PHARMACEUTICAL RESEARCH CO., LTD., ZHEJIANG ACEA PHARMACEUTICALS CO., LTD.
    Inventors: Long MAO, Jia LIU, Yile CHEN, Yuning HUA, Kunhua DONG, Liang CHEN, Bojie WENG, Xiaopeng MO, Kongen DAI, Yimei BAO, Jian WU, Bin LIANG, Guanglin ZHOU, Zhen WANG
  • Publication number: 20210300931
    Abstract: Disclosed methods of making certain pyrrolopyrimidine derivatives, which are useful in the treatment of proliferation disorders and other diseases related to the dysregulation of kinase (such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3(D835Y), ITK, JAK1, JAK2, JAK3, TEC AND TXK) and/or the respective pathways, salts, polymorphs, and amorphous forms of said compounds, synthetic intermediates for preparing said compounds, and pharmaceutical compositions comprising said compounds and methods for making such compositions.
    Type: Application
    Filed: April 7, 2017
    Publication date: September 30, 2021
    Applicants: ACEA Therapeutics, Inc., Hangzhou ACEA Pharmaceutical Research Co., Ltd., Zhejiang ACEA Pharmaceuticals Co., Ltd.
    Inventors: Long MAO, Jia LIU, Yile CHEN, Yuning HUA, Kongen DAI, Yimei BAO, Bojie WENG, Xi-aopeng MO, Jian WU, Xiao XU, Wanhong XU, Xiaobo WANG