Abstract: A target-directed, magnetically enhanced system and method for detoxification of patients. The system comprises a first fluid circuit for circulation of biological fluid and a second fluid circuit for co-circulation of biological fluid. The first fluid circuit comprises, in the following order: a first fluid circuit inlet (10), a reaction chamber (2), an equipment comprising one or more elements that separate the magnetic microspheres from the biological fluid, and a first fluid circuit outlet (13). The second fluid circuit initiates after the first fluid circuit inlet (10) and terminates before the first fluid circuit outlet (13). The system and method can be used to quickly and effectively remove toxins, infectious agents, allergens, cancer cells, and other unwanted substances from a patient, and provide extracorporeal blood or plasma treatment.