Patents Assigned to HANGZHOU NORMAL UNIVERSITY
  • Patent number: 12213614
    Abstract: A continuous boiling water preparation method based on gas-liquid two-phase object detection comprises a flow regulator, a heater, a temperature sensor, a two-phase object detection sensor and a controller; the flow regulator is used for injecting a cold water flow obtained from the outside into a water inlet of the heater; the heater heats up according to heating power provided by the controller; the two-phase object detection sensor and the temperature sensor are connected behind a water outlet of the heater, and when a boiling water flow flows through the two sensors, a gas-liquid ratio signal and a temperature signal are obtained respectively, and transmitted to the controller; and the controller transmits a signal indicating required heating power to the heater or transmits a signal indicating a required flow value to the flow regulator through calculation to execute output after receiving the gas-liquid ratio signal.
    Type: Grant
    Filed: April 2, 2024
    Date of Patent: February 4, 2025
    Assignee: Hangzhou Normal University
    Inventors: Lida Dong, Wen Dong
  • Patent number: 12180519
    Abstract: Disclosed are a cocaine esterase mutant and use thereof. The cocaine esterase mutant is obtained by mutating a wildtype cocaine esterase, an amino acid sequence of the wildtype cocaine esterase is shown as SEQ ID No. 1, the cocaine esterase mutant is T172R/G173Q/L196C/I301C, or additionally added with V116K point mutation, or additionally added with A51 site mutation, and the A51 site mutation is L, Y, V, F or W. Catalytic efficiency of the cocaine esterase mutant screened on a cocaine toxic metabolite benzoylecgonine is greatly improved compared with that of a wildtype enzyme.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: December 31, 2024
    Assignee: Hangzhou Normal University
    Inventors: Xiabin Chen, Jianzhuang Yao, Shurong Hou, Xingyu Deng, Yun Zhang, Junsen Tong
  • Patent number: 12048715
    Abstract: Disclosed are a cis-platinum cross-linked protein hydrogel and a preparation method thereof. Main components of the cis-platinum cross-linked protein hydrogel comprise the following ingredients in percentage by mass: 0.5% to 5.0% drug, 6.0% to 50.0% serum albumin and 47.0% to 93.0% solvent medium; a carboxyl group on a surface of the serum albumin and the drug form a coordinate bond; and the drug is cis-platinum. A hydrogel preparation is simple in structure and easy to prepare, and the used cis-platinum has dual effects: a cross-linking agent for promoting the formation of protein hydrogels and an antitumor drug for exerting a tumor inhibition curative effect. The strategy simplifies the carrier design and reduces potential toxic side effects. The protein carboxyl limits the release of cis-platinum through a coordination effect so that reduce the burst release of the loaded drugs drastically.
    Type: Grant
    Filed: August 29, 2023
    Date of Patent: July 30, 2024
    Assignee: Hangzhou Normal University
    Inventors: Shuangjiang Yu, An Yan, Shu Wei, Hongcheng Sun, Junqiu Liu
  • Patent number: 11981630
    Abstract: Disclosed are an abietane type diterpene compound, a preparation method and an application thereof, relating to the technical field of anti-tumor compounds, where the compound has a chemical structure as shown in the following formula I: Leucosceptrum canum is extracted to prepare the abietane type diterpene compound according to the present application, and the prepared compound is effectively applied in inhibiting human lung cancer cell A549 and human myeloid leukemia cell HL-60.
    Type: Grant
    Filed: January 31, 2023
    Date of Patent: May 14, 2024
    Assignee: HANGZHOU NORMAL UNIVERSITY
    Inventors: Mingfeng Xu, Xiaohong Deng, Jinfeng Liang, Yidi Chen, Jing Ren, Qin Zhu
  • Patent number: 11932717
    Abstract: Disclosed are a green synthesis method of an antibacterial super-porous hydrogel, a product of the antibacterial super-porous hydrogel and an application of the antibacterial super-porous hydrogel to degradation of various pollutants in wastewater treatment. The super-porous hydrogel based on poly (ionic liquid) is prepared by copolymerization of an imidazole type ionic liquid with double bonds and polyethylene glycol diacrylate (PEGDA) as a cross-linker. In the reaction system, water is a good solvent for the monomer ionic liquid and PEGDA, but a poor solvent for the poly (ionic liquid); when an initial concentration of the ionic liquid is higher than 25%, the phase separation typically proceeds through poly(ionic liquid) formation, interconnected networks with macroporous structure could be obtained by photo-crosslinking.
    Type: Grant
    Filed: May 23, 2023
    Date of Patent: March 19, 2024
    Assignee: Hangzhou Normal University
    Inventors: Yuanyuan Liang, Yongjin Li
  • Patent number: 11912596
    Abstract: Disclosed is a method for treating phenol wastewater. The method includes the following step: adding a hydrophobic phthalocyanine as a catalyst, and H2O2 as an oxidant into the phenol wastewater. The hydrophobic phthalocyanine is obtained by decorating a hydrophobic group on a bacterial cellulose-metal phthalocyanine with a silane coupling agent; the bacterial cellulose-metal phthalocyanine is obtained by mixing a metal phthalocyanine into a bacterial cellulose medium, biologically culturing with an acetic acid bacterium, and then heating and reducing the mixture; and the metal phthalocyanine is nitro-sulfonic metal phthalocyanine.
    Type: Grant
    Filed: September 22, 2023
    Date of Patent: February 27, 2024
    Assignee: Hangzhou Normal University
    Inventors: Jiachi Huang, Shiliang Chen
  • Patent number: 11807559
    Abstract: Disclosed is an application of a hydrophobic phthalocyanine as a heterogeneous catalyst in oxidizing phenol wastewater by hydrogen peroxide. A hydrophobic silane is decorated on a bacterial cellulose-metal phthalocyanine heterogeneous catalyst to obtain a hydrophobic phthalocyanine heterogeneous catalyst; during the catalytic degradation of phenols, the obtained catalyst is capable of adjusting a concentration of hydrogen peroxide oxidant around the catalyst. A preparation method of the hydrophobic phthalocyanine comprises: 1. preparing a mixed solution of a bacterial cellulose medium containing metal phthalocyanine; 2. adding acetic acid bacterium into the mixed solution obtained in step 1 for biological culture; 3. heating the product obtained in step 2, and taking out a solid for cleaning and drying; 4. preparing a hydrophobic silane solution; and 5. immersing the product obtained in step 3 into the solution obtained in step 4, and taking out a solid after reaction for cleaning and drying.
    Type: Grant
    Filed: November 3, 2022
    Date of Patent: November 7, 2023
    Assignee: Hangzhou Normal University
    Inventors: Jiachi Huang, Shiliang Chen
  • Patent number: 11738083
    Abstract: The present disclosure proposes a BODIPY-based rhombic metal ring, its preparation method, and application in near-infrared region imaging, specifically a BODIPY-based rhombic metal ring M absorbed in the near-infrared first region formed based on a BODIPY-based 120° bipyridyl BODIPY ligand molecule 1 and a 60° methoxy platinum acceptor molecule 2, self-assembled by Pt—N metal coordination bonds. The BODIPY-based rhombic supramolecular metal ring has good solubility and near-infrared fluorescence emission, and it is wrapped by commercial amphiphilic polymer F127 carrier to form F127/M nanoparticles, which successfully have excellent photodynamic and photothermal therapeutic effects in vitro.
    Type: Grant
    Filed: March 10, 2023
    Date of Patent: August 29, 2023
    Assignee: Hangzhou Normal University
    Inventors: Shouchun Yin, Yang Li, Huayu Qiu
  • Patent number: 11722887
    Abstract: A privacy protection authentication method based on a wireless body area network may be applied to a smart home care system. The method provides an authentication method for two-way authentication and key verification between a device and a cloud server, can ensure identities of the device and the cloud server to be valid and prevent network information security from being affected by external invasion attacks. A physical unclonable function and an elliptic curve cryptography algorithm are introduced to encrypt key data in the authentication process, so that the whole authentication process is in a safe environment, and the security of the authentication process is further improved through adding and removing functions of a third-party identity. The privacy protection authentication protocol method can resist replay attacks and smart card impersonation attacks, the whole authentication process is safe and efficient, and has a high application value in smart home care scenes.
    Type: Grant
    Filed: August 23, 2022
    Date of Patent: August 8, 2023
    Assignee: HANGZHOU NORMAL UNIVERSITY
    Inventors: Qi Xie, Xiumei Li, Dongnan Liu, Zixuan Ding, Bin Hu, Xiao Tan, Lidong Han
  • Patent number: 11577228
    Abstract: The present invention relates to the field of catalysts, and provides a porous layered transition metal dichalcogenide (TMD) and a preparation method and use thereof. The preparation method includes the following steps: (1) mixing silica microspheres, a transition metal salt and an elemental chalcogen, and pressing to obtain a tablet, the silica microspheres having a same or different particle diameters; and (2) sintering the tablet under hydrogen, and removing the silica microspheres to obtain the porous layered TMD. The porous layered TMD prepared by the method of the present invention has a high lattice edge exposure, which provides more active sites and higher catalytic activity, so the porous layered TMD can effectively catalyze the oxidation of alcohols to aldehydes or sulfides to sulfoxides under visible light irradiation.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: February 14, 2023
    Assignee: HANGZHOU NORMAL UNIVERSITY
    Inventors: Cheng Wang, Weiming Xu, Huilin Zheng, Pengfei Zhang, Hongyun Shen, Xiaoling Li
  • Patent number: 11414415
    Abstract: The present invention relates to the technical field of chemical synthesis of pharmaceutical chemicals, and provides a 6H-imidazo[4,5,1-ij]quinolone, a synthesis method and use thereof. 6H-imidazo[4,5,1-ij]quinolone derivatives provided by the present invention are a novel group of active quinolone derivatives, which have tumor cell inhibition activity and exhibit IC50 values equivalent to anti-lung cancer drug osimertinib; these quinolone derivatives have a broad application prospect in the preparation of antitumor drugs. The 6H-imidazo[4,5,1-ij]quinolone provided by the present invention is of high research and application value and has potential application prospects in fields of pharmaceutical chemicals, materials, dyes, etc. The present invention uses thioquinolinamide as a raw material to synthesize 6H-imidazo[4,5,1-ij]quinolones, featuring simple operation, excellent selectivity, high yield, mild reaction conditions, and easy product separation.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: August 16, 2022
    Assignee: HANGZHOU NORMAL UNIVERSITY
    Inventors: Pengfei Zhang, Wei Huang, Chao Shen, Jun Xu, Jiabin Shen, Weiming Xu
  • Publication number: 20220202635
    Abstract: An automatic cleaning method and a cleaning bed for a patient of gatism are provided. The cleaning bed includes a bed body, a bed plate is arranged on the bed body and is provided with a through groove therein, a bed bottom plate is arranged on a lower part of the bed body, a lifting mechanism is arranged on the bed bottom plate and is provided with a soft cushion thereon, a fabric bracket is arranged under the bed plate and is provided with a material roller thereon, a pressing roller bracket is arranged under the bed plate and at one side close to the fabric bracket and is provided with provided with a first pressing roller and a second pressing roller.
    Type: Application
    Filed: July 16, 2021
    Publication date: June 30, 2022
    Applicants: Hangzhou Normal University
    Inventors: Meijuan CAO, Binyu ZHAO, Guohe FENG, Wei ZHANG, Hangsai WANG, Tong WU, Xiaoxia LUO, Yucai HONG
  • Patent number: 11242307
    Abstract: A method for preparing alkynyl 2-halo-2,2-difluoroacetate is disclosed. The method comprises: subjecting a 2-halo-2,2-difluoro acetic acid, an alkynol, and a catalyst to an esterification reaction in a solvent, to obtain alkynyl 2-halo-2,2-difluoroacetate, wherein the catalyst includes one or more of sulfuric acid, phosphoric acid and p-toluenesulfonic acid.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: February 8, 2022
    Assignees: Hangzhou Transfar Fine Chemical Co., Ltd., Hangzhou Normal University, Zhejiang Transfar Functional New Material Co., Ltd.
    Inventors: Pengfei Zhang, Shengpeng Wang, Wanmei Li, Weiming Xu, Bajin Chen, Xiaojun Wang
  • Patent number: 11161818
    Abstract: A novel quinolone derivative and methods of its preparation are described in which the novel derivative comprises a diphenyl ether substituent on the nitrogen atom at the 1-position of the main quinolone ring. The novel derivative is shown to have antibacterial and anti-tumor cell activity.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: November 2, 2021
    Assignee: HANGZHOU NORMAL UNIVERSITY
    Inventors: Pengfei Zhang, Wanmei Li, Weiming Xu, Haifeng Wu
  • Patent number: 11161809
    Abstract: The disclosure provides processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac, relating to the field of medicine. The former comprises mixing 6-fluoro-2-methyl-1-indanone, cyanoacetic acid, a first organic solvent and an acetic acid-based catalyst to proceed with a first condensation reaction to give a first condensation reaction solution, which contains 5-fluoro-2-methyl-3-indanacetonitrile; and mixing the first condensation reaction solution, per se, with a base, a second organic solvent and 4-(methylthio)benzaldehyde to proceed with a second condensation reaction to give 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile. The process is a one-pot process without separation of 5-fluoro-2-methyl-3-indanacetonitrile from the solvent, shortening the synthetic route, simplifying the preparation process and improving the 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile yield.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: November 2, 2021
    Assignees: HANGZHOU NORMAL UNIVERSITY, HANGZHOU LOOP BIOTECH CO., LTD
    Inventors: Weiming Xu, Wanmei Li, Lianzhi Tao, Pengfei Zhang, Hongyun Shen, Dongxiang Feng
  • Publication number: 20210276947
    Abstract: The disclosure provides processes for preparing 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile and for preparing sulindac, relating to the field of medicine. The former comprises mixing 6-fluoro-2-methyl-1-indanone, cyanoacetic acid, a first organic solvent and an acetic acid-based catalyst to proceed with a first condensation reaction to give a first condensation reaction solution, which contains 5-fluoro-2-methyl-3-indanacetonitrile; and mixing the first condensation reaction solution, per se, with a base, a second organic solvent and 4-(methylthio)benzaldehyde to proceed with a second condensation reaction to give 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile. The process is a one-pot process without separation of 5-fluoro-2-methyl-3-indanacetonitrile from the solvent, shortening the synthetic route, simplifying the preparation process and improving the 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indanacetonitrile yield.
    Type: Application
    Filed: April 21, 2020
    Publication date: September 9, 2021
    Applicants: HANGZHOU NORMAL UNIVERSITY, HANGZHOU LOOP BIOTECH CO., LTD
    Inventors: Weiming XU, Wanmei LI, Lianzhi TAO, Pengfei ZHANG, Hongyun SHEN, Dongxiang FENG
  • Patent number: 10611721
    Abstract: The present invention provides a method for preparing levobunolol hydrochloride. In the present invention S-1-tert-butyl-epoxy methylamine is subjected to a substitution reaction with 5-hydroxy-1-tetralone, and acidified to obtain the target product levobunolol hydrochloride. The method provided by the present invention greatly improves the regioselectivity of the reaction, avoids the occurrence of side reactions, and effectively improves the yield and optical purity of levobunolol hydrochloride, with the yield being 87.3%, and the ee value being over 99%.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: April 7, 2020
    Assignees: HANGZHOU NORMAL UNIVERSITY, HANGZHOU LOOP BIOTECH CO., LTD
    Inventors: Weiming Xu, Pengfei Zhang, Dongxiang Feng, Lianzhi Tao
  • Patent number: 10604466
    Abstract: The present invention provides a method for preparing a resveratrol compound, and belongs to the technical field of organic synthesis. In the present invention, first alkoxy-substituted benzyl halide, alkoxy-substituted benzaldehyde and a metal catalyst are subjected to oxidative addition and reduction elimination reactions to obtain alkoxy-substituted diphenylethanone; and then the alkoxy-substituted diphenylethanone and a metal catalyst are subjected to reduction, trans elimination and selective debenzylation reactions under a hydrogen atmosphere to obtain the resveratrol compound. In the preparation method of the present invention, the hydrogenation reduction, trans elimination and selective debenzylation reactions can be achieved just by a one-pot process, where the reaction directly obtains a trans olefin, thereby avoiding the formation of a isomer; and also the reaction selectively catalyzes debenzylation to eliminate Lewis acids from the source, and has the advantage of a high yield.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: March 31, 2020
    Assignees: HANGZHOU NORMAL UNIVERSITY, GREAT FOREST BIOMEDICAL LTD.
    Inventors: Weiming Xu, Wanmei Li, Xiaoling Li, Pengfei Zhang, Jinsong Wang, Kejie Chai
  • Publication number: 20200071259
    Abstract: The present invention provides a method for preparing levobunolol hydrochloride. In the present invention S-1-tert-butyl-epoxy methylamine is subjected to a substitution reaction with 5-hydroxy-1-tetralone, and acidified to obtain the target product levobunolol hydrochloride. The method provided by the present invention greatly improves the regioselectivity of the reaction, avoids the occurrence of side reactions, and effectively improves the yield and optical purity of levobunolol hydrochloride, with the yield being 87.3%, and the ee value being over 99%.
    Type: Application
    Filed: October 18, 2018
    Publication date: March 5, 2020
    Applicants: HANGZHOU NORMAL UNIVERSITY, HANGZHOU LOOP BIOTECH CO., LTD
    Inventors: Weiming Xu, Pengfei Zhang, Dongxiang Feng, Lianzhi Tao
  • Patent number: 10500568
    Abstract: The present invention discloses a core-shell structure supported tungsten composite catalyst and a preparation method and use thereof. Most of the existing synthesis methods of the main ring of quinolone drugs have the defects of many synthesis steps, cumbersome operation, large amount of three wastes, higher costs and the like. The present invention prepares a magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, by preparing Fe3O4 colloid and SiO2/Fe3O4 composite nano-particles. This magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, is used to catalyze and synthesize quinolone compounds. The present invention provides an efficient preparation method of quinolone compounds using a catalyst which can be recovered by magnetic separation and recycled.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 10, 2019
    Assignees: Hangzhou Normal University, Zhejiang Benli Technology Co., Ltd.
    Inventors: Pengfei Zhang, Chao Shen, Xiaoling Li, Jun Xu, Haining Gu