Patents Assigned to Hanmi Pharm. Co., Ltd.
  • ATORVASTATIN STRONTIUM SALT AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
    Publication number: 20100120888
    Abstract: This invention provides atorvastatin strontium salt or its hydrates or polymorphs having improved water solubility, which is useful for the prevention or treatment of hyperlipidemia and hypercholesterolemia, and a pharmaceutical composition comprising same.
    Type: Application
    Filed: January 21, 2008
    Publication date: May 13, 2010
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Eun Sook Kim, Sun Young Jang, Bo Sung Kwon, Sangmin Yun, Kwee Hyun Suh, Gwan Sun Lee
  • Physiologically Active Polypeptide Conjugate Having Prolonged In Vivo Half-Life
    Publication number: 20100105869
    Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a polypeptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.
    Type: Application
    Filed: October 22, 2009
    Publication date: April 29, 2010
    Applicant: Hanmi Pharm. Co., Ltd.
    Inventors: Young-Min Kim, Dae-Jin Kim, Sung-Min Bae, Chang-Ki Lim, Se-Chang Kwon, Gwan-Sun Lee
  • Method for preparing rapidly disintegrating formulation for oral administration and apparatus for preparing and packing the same
    Publication number: 20100105783
    Abstract: A method and packaging machine for preparing rapidly disintegrating formulations for oral administration are disclosed. The present invention is characterized in that a powdery mixture including a pharmaceutically active ingredient and a sugar or a sugar alcohol powder is filled into a packaging material and, thereafter, the mixture, filled in the packaging material, is heated. The present invention can simply and economically prepare an oral formulation which undergoes rapid disintegration in the oral cavity and provides for high-quality administration to patients.
    Type: Application
    Filed: December 23, 2009
    Publication date: April 29, 2010
    Applicant: Hanmi Pharm. Co., Ltd.
    Inventors: Chang Hyun Lee, Jong Soo Woo, Hong Gi Yi, Kyeong Soo Kim, Ho Taek Yim
  • Modified human granulocyte-colony stimulating factor and process for producing same
    Patent number: 7704709
    Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: April 27, 2010
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Se-Chang Kwon, Sung-Youb Jung, Sung-Min Bae, Gwan-Sun Lee
  • Sustained release composition for oral administration of drugs
    Patent number: 7704526
    Abstract: A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl methylcellulose and propylene glycol alginate as a gel hydration accelerator, which is capable of maintaining a constant drug level in blood for 24 hours or more. Due to rapid gel hydration without forming a non-gelated core, the drug release rate follows zero order kinetics and does not significantly vary with the degree of gastrointestinal motility.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: April 27, 2010
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Jong-Soo Woo, Moon-Hyuk Chi
  • METHOD OF PREPARING S-(-)-AMLODIPINE OR A SALT THEREOF AND AN INTERMEDIATE USED THEREIN
    Publication number: 20100099884
    Abstract: The present invention provides a novel method for preparing S-(?)-amlodipine having a high optical purity or a salt thereof and an intermediate used therein.
    Type: Application
    Filed: January 29, 2008
    Publication date: April 22, 2010
    Applicant: HANMI PHARM. CO., LTD
    Inventors: Sun Young JANG, Sungbum Kim, Sangmin Yun, Hyo Jeong Bang, Han Kyong Kim, Kwee Hyun Suh
  • METHOD OF PREPARING MONTELUKAST AND INTERMEDIATES USED THEREIN
    Publication number: 20100099876
    Abstract: The present invention relates to a method for preparing montelukast, an inhibitor against leukotrienes, and an intermediate used therein. According to the inventive method, high-purity montelukast or its sodium salt can be prepared in a high yield.
    Type: Application
    Filed: December 11, 2007
    Publication date: April 22, 2010
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Gwan Sun Lee, Young-Kil Chang, Jaeheon Lee, Chul Hyun Park, Eun-Ju Park, Jaeho Yoo
  • STABLE ANHYDROUS CRYSTALLINE DOCETAXEL AND METHOD FOR THE PREPARATION THEREOF
    Publication number: 20100099897
    Abstract: The present invention provides a stable anhydrous crystalline docetaxel which has anti-tumor and anti-leukemia activity, and method for the preparation thereof.
    Type: Application
    Filed: April 10, 2008
    Publication date: April 22, 2010
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Namdu Kim, Woo Seob Shin, Jaehyuk Jung, Gi Jeong Kim, Seung Hwan Cho, Eun Jung Lim, Youngho Moon, Young-Kil Chang, Gwan Sun Lee
  • METHOD OF PREPARING DOCETAXEL AND INTERMEDIATES USED THEREIN
    Publication number: 20100099896
    Abstract: The present invention relates to a novel method for preparing docetaxel having anti-tumor and anti-leukemia activity, and intermediates useful for preparing docetaxel.
    Type: Application
    Filed: December 3, 2007
    Publication date: April 22, 2010
    Applicant: HANMI PHARM. CO. LTD
    Inventors: Nam Du Kim, Wooseob Shin, Jaehyuk Jung, Dong Jun KIm, Gi Jeong Kim, Young Ho Moon, Young-Kil Chang, Gwan Sun Lee
  • COMPLEX FORMULATION FOR PREVENTING OR TREATING OSTEOPOROSIS WHICH COMPRISES SOLID DISPERSION OF VITAMIN D OR ITS DERIVATIVE AND BISPHOSPHONATE
    Publication number: 20100048511
    Abstract: Provided is a solid dispersion comprising vitamin D or a derivative thereof and a cyclodextrin; a complex formulation for the prevention or treatment of osteophorosis, which includes the solid dispersion and a bisphosphonate; and a method for preparing said complex formulation. The complex formulation can maintain a constant therapeutic level of vitamin D or a derivative thereof through its improved drug stability, while enhancing the patient compliance by minimizing inconvenience and adverse effects when administered to patients.
    Type: Application
    Filed: November 6, 2007
    Publication date: February 25, 2010
    Applicant: HANMI PHARM CO., LTD.
    Inventors: Jong Soo Woo, Hong Gi Yi, Ju Nam Jin
  • Method of preparing clopidogrel and intermediates used therein
    Patent number: 7652140
    Abstract: Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: January 26, 2010
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Eun Sook Kim, Hee Cheol Kim, Bo Sung Kwon, Sangmin Yun, Mi Young Ko, Cheol Kyung Kim, Kwee Hyun Suh
  • Controlled Release Complex Formulation For Oral Administration of Medicine For Diabetes and Method For The Preparation Thereof
    Publication number: 20100003289
    Abstract: A controlled release combination formulation for oral administration comprising a) a controlled release portion containing metformin or a pharmaceutically acceptable salt thereof as an active ingredient, and a combination of a polyethylene oxide and a natural gum as a carrier for controlled release; and b) a rapid-release portion containing a sulfonylurea-based medicine for treating diabetes as an active ingredient coated on the controlled release portion is useful for the treatment of diabetes, for it is capable of maintaining an effective concentration of the medicines in blood at a constant level.
    Type: Application
    Filed: December 28, 2005
    Publication date: January 7, 2010
    Applicant: Hanmi Pharm, Co., Ltd.
    Inventors: Jong Soo Woo, Hong Gi Yi, Moon Hyuk Chi, Young Hun Kim
  • (S)-(-)-Amlodipine Camsylate or Hydrate Thereof And Pharmaceutical Composition Comprising Same
    Publication number: 20090326234
    Abstract: Disclosed is (S)-(?)-amlodipine camsylate or a hydrate thereof having good photostability and high solubility, and a pharmaceutical composition comprising same, which can be efficiently used in treating cardiovascular diseases.
    Type: Application
    Filed: July 16, 2007
    Publication date: December 31, 2009
    Applicant: Hanmi Pharm Co., Ltd.
    Inventors: Jaeheon Lee, Moon Sub Lee, Weon Ki Yang, Jaeho Yoo, Jae-Chul Lee, Chang-Ju Choi, Han Kyong Kim, Young-Kil Chang, Gwansun Lee
  • Method for the preparation of D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative
    Patent number: 7638642
    Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: December 29, 2009
    Assignee: Hanmi Pharm, Co., Ltd
    Inventors: Jaeheon Lee, Gha-Seung Park, Moonsub Lee, Cheol-Kyong Kim, Jae-Chul Lee, Young-Kil Chang, Gwan-Sun Lee
  • METHOD PREPARATION CLOPIDOGREL AND INTERMEDIATES USED THEREIN
    Publication number: 20090318701
    Abstract: Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
    Type: Application
    Filed: August 28, 2009
    Publication date: December 24, 2009
    Applicant: HANMI PHARM CO., LTD.
    Inventors: Eun Sook KIM, Hee Cheol KIM, Bo Sung KWON, Sangmin YUN, Mi Young KO, Cheol Kyung KIM, Kwee Hyun SUH
  • Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
    Publication number: 20090318375
    Abstract: This invention provides a crystalline azithromycin L-malate monohydrate for treating various microbial infections, which has high thermostability, solubility and non-hygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
    Type: Application
    Filed: June 6, 2003
    Publication date: December 24, 2009
    Applicant: Hanmi Pharm Co., Ltd
    Inventors: Bo Sung Kwon, Eun Sook Kim, Hee Cheol Kim, Sangmin Yun, Myoung-sil Ko, Tae Hun Song, Han Kyong Kim, Kwee Hyun Suh, Gwansun Lee
  • P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same
    Patent number: 7625926
    Abstract: The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: December 1, 2009
    Assignee: Hanmi Pharm. Co., Ltd
    Inventors: Keuk Chan Bang, Mi Young Cha, Young Gil Ahn, Young Jin Ham, Maeng Sup Kim, Gwan Sun Lee
  • Method for preparing clopidogrel 1,5-naphthalenedisulfonate or hydrate thereof
    Patent number: 7612207
    Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: November 3, 2009
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Kwee Hyun Suh, Sang Min Yun, Eun Sook Kim, Gwan Sun Lee
  • Crystalline S-Omeprazole Strontium Hydrate, Method For Preparing Same, And Pharmaceutical Composition Containing Same
    Publication number: 20090258908
    Abstract: This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 15, 2009
    Applicant: Hanmi Pharm. Co., Ltd.
    Inventors: Tae Hee HA, Hee Sook OH, Won Jeoung KIM, Chang Hee PARK, Eun Young KIM, Young Hoon KIM, Kwee Hyun SUH, Gwan Sun LEE
  • PHARMACEUTICAL COMPOSITION CONTAINING CLOPIDOGREL CAMPHORSULFONATE OR POLYMORPHIC FORMS THEREOF
    Publication number: 20090209576
    Abstract: A pharmaceutical composition of the present invention which comprises clopidogrel camphorsulfonate of formula (I) or its polymorphic forms as an active ingredient is useful for treating or preventing a platelet aggregation-associated disease.
    Type: Application
    Filed: March 15, 2007
    Publication date: August 20, 2009
    Applicant: HANMI PHARM. CO., LTD.
    Inventors: Won Jeoung Kim, Han Kyong Kim, Kwee Hyun Suh, Gwan Sun Lee