Patents Assigned to Hanmi Science
  • Process for preparing voriconazole
    Patent number: 8263769
    Abstract: Optically pure voriconazole can be prepared in a high yield by a) subjecting 1-(2,4-difluorophenyl)-2(1H-1,2,4-triazol-1-yl)ethanone to Reformatsky-type coupling reaction with a substituted thiopyrimidine derivative to obtain a desired (2R,3S)/(2S,3R)-enantiomeric pair; b) removing the thiol derivative from the enantiomer to obtain racemic voriconazole; and c) isolating the racemic voriconazole by way of optical resolution using an optically active acid.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: September 11, 2012
    Assignee: Hanmi Science
    Inventors: Young Ho Moon, Moon Sub Lee, Jae Ho Yoo, Ji Sook Kim, Han Kyong Kim, Chang Ju Choi, Young Kil Chang, Gwan Sun Lee