Abstract: The use of protein H, and fragments or derivatives thereof, as cytostatic agents, especially in the treatment of diseases involving undesired cell proliferation.
Type:
Grant
Filed:
May 11, 2000
Date of Patent:
December 21, 2004
Assignee:
Hansa Medical AB
Inventors:
Lars H. Björck, Inga-Maria Frick, Tomas Borje Leandersson, Eugen Jan Karol Axcrona
Abstract: A protein from Streptococcus pyogenes, serotype M1 has been characterized. This protein, called protein SIC, plays a role in S. pyogenes pathogenicity and virulence. It inhibits hemolysis by interacting with the plasma proteins clusterin, and members of the cystatin protein super family such as hisitidine rich glycoprotein (HRG). The protein comprises at least one of the following partial amino acid sequences: (a) glu thr tyr thr ser arg asn phe; (b) asp trp ser gly asp asp trp pro glu asp asp trp; (c) arg ser gly val gly leu ser gln tyr gly trp ser; (d) trp ser ser asp lys lys asp glu thr glu asp lyr thr; (e) gly thr gly tyr glu lys arg asp asp trp gly gly pro gly; (f) lys arg asp asp trp arg gly pro gly his ile pro lys pro. The protein and antibodies specific for the protein can be used in analytical procedures for determining the present of virulent Streptococcus pyrogens in a sample. The protein can also be used in vaccine compositions.
Type:
Grant
Filed:
September 8, 1998
Date of Patent:
June 10, 2003
Assignee:
Hansa Medical AB
Inventors:
Per Åkesson, Lars Björck, Anders Sjoholm