Patents Assigned to HAPLNSCIENCE INC.
  • Publication number: 20250152663
    Abstract: Disclosed are a pharmaceutical composition for prevention or treatment of dry eye disease, including hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient, and a method for preventing or treating dry eye disease by using same. According to the present disclosure, dry eye disease may be effectively and stably prevented or treated, and side effects are reduced as compared to conventional products.
    Type: Application
    Filed: December 29, 2022
    Publication date: May 15, 2025
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Yong Soon Kim, Moon Jung Back, Dong Kyu Chae, Jung Hoon Pyo, David Kim
  • Patent number: 12268728
    Abstract: Provided are a recombinant hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for preventing or treating pulmonary diseases, the composition comprising at least one selected from the group consisting of HAPLN1 (hyaluronan and proteoglycan link protein 1) protein, a gene coding for the HAPLN1 protein, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene as an active ingredient. The recombinant HAPLN1 according to the present disclosure may have superior effects of improving alveolar damage caused by aging or elastin reduction, and thus may effectively prevent or treat pulmonary diseases, such as chronic bronchitis, asthma, emphysema, and chronic obstructive pulmonary disease.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: April 8, 2025
    Assignee: HAPLNSCIENCE, INC.
    Inventors: Dae Kyong Kim, Yong Wei Piao, Ji Min Jang, Dan Zhou, So Yoon Yun, Bo Kyung Park
  • Publication number: 20230242959
    Abstract: Provided are a medium composition for culturing animal cells for producing a recombinant extracellular matrix protein, a method of producing the recombinant extracellular matrix protein with high purity, and a method of assaying a monomer of the recombinant extracellular matrix protein.
    Type: Application
    Filed: December 29, 2021
    Publication date: August 3, 2023
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Yo Kyung Chung, Sung Mi Hwang
  • Publication number: 20230158106
    Abstract: The present disclosure relates to a composition for the prevention, improvement, or treatment of cartilage-related diseases or symptoms, the composition including hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. In detail, the present disclosure provides a composition for regenerating cartilage, a composition for the prevention, improvement, or treatment of osteoarthritis, or a composition for regenerating growth plate cartilage, each composition including HAPLN1 as an active ingredient.
    Type: Application
    Filed: February 28, 2019
    Publication date: May 25, 2023
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Ji Min Jang
  • Publication number: 20220305077
    Abstract: Provided are a recombinant hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for preventing or treating pulmonary diseases, the composition comprising at least one selected from the group consisting of HAPLN1 (hyaluronan and proteoglycan link protein 1) protein, a gene coding for the HAPLN1 protein, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene as an active ingredient. The recombinant HAPLN1 according to the present disclosure may have superior effects of improving alveolar damage caused by aging or elastin reduction, and thus may effectively prevent or treat pulmonary diseases, such as chronic bronchitis, asthma, emphysema, and chronic obstructive pulmonary disease.
    Type: Application
    Filed: February 2, 2021
    Publication date: September 29, 2022
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Yong Wei Piao, Ji Min Jang, Dan Zhou, So Yoon Yun, Bo Kyung Park
  • Publication number: 20220290201
    Abstract: Provided are a medium composition for culturing animal cells for producing a recombinant extracellular matrix protein, a method of producing the recombinant extracellular matrix protein with high purity, and a method of assaying a monomer of the recombinant extracellular matrix protein.
    Type: Application
    Filed: May 31, 2022
    Publication date: September 15, 2022
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Yo Kyung Chung, Sung Mi Hwang
  • Publication number: 20220202899
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating hair loss, comprising hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. When administered, the HAPLN1 protein of the present invention grows hair by promoting the proliferation of hair germinal matrix cells through a Ras-ERK1/2 signaling pathway activated by a TGF-? protein.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 30, 2022
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Hae Chan Ha, Ji Min Jang, In Chul Shin, Moon Jung Back, Dan Zhou
  • Patent number: 11213572
    Abstract: Provided is a method of regenerating cartilage tissues by treatment with hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for regenerating cartilage, the composition including HAPLN1 as an active ingredient. According to the present disclosure, the HAPLN1 protein may have cartilage formation-stimulating ability and articular cartilage regeneration ability, may increase an expression level of TGF-? receptor I of chondrocytes to increase a component ratio of cells having cartilage formation ability, and to induce regeneration of cartilage tissues. Accordingly, the HAPLN1 protein of the present disclosure, which is a novel composition regulating TGF-? signaling, may be usefully applied as a pharmaceutical composition for regenerating cartilage, a health food composition for regenerating cartilage, or a reagent composition for regenerating cartilage.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: January 4, 2022
    Assignee: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Ji Min Jang
  • Patent number: 11202749
    Abstract: The present disclosure relates to HAPLN1 protein of an aged individual. The HAPLN1 protein exhibits reduced expression with aging, and when administered, its effect in alleviating and reversing skin aging including wrinkles is excellent. Therefore, by exploiting the difference in expression, provided are a biomarker composition for measuring skin aging, capable of diagnosing skin aging; a kit; and a method of screening for skin aging alleviating agents, comprising detecting the expression level of HAPLN1 protein or HAPLN1 gene. In addition, provided are a pharmaceutical composition, cosmetic composition, or health functional food for preventing or alleviating skin aging, and a cosmetic composition or health functional food for alleviating wrinkles, each containing any one or more selected from the group consisting of HAPLN1 protein, a gene encoding the same, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: December 21, 2021
    Assignee: HAPLNSCIENCE INC.
    Inventors: Dae Kyong Kim, Zhicheng Fu, Moon Jung Back
  • Publication number: 20200276278
    Abstract: Provided is a method of regenerating cartilage tissues by treatment with hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for regenerating cartilage, the composition including HAPLN1 as an active ingredient. According to the present disclosure, the HAPLN1 protein may have cartilage formation-stimulating ability and articular cartilage regeneration ability, may increase an expression level of TGF-? receptor I of chondrocytes to increase a component ratio of cells having cartilage formation ability, and to induce regeneration of cartilage tissues. Accordingly, the HAPLN1 protein of the present disclosure, which is a novel composition regulating TGF-? signaling, may be usefully applied as a pharmaceutical composition for regenerating cartilage, a health food composition for regenerating cartilage, or a reagent composition for regenerating cartilage.
    Type: Application
    Filed: February 28, 2020
    Publication date: September 3, 2020
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong KIM, Ji Min JANG
  • Publication number: 20200000700
    Abstract: The present disclosure relates to HAPLN1 protein of an aged individual. The HAPLN1 protein exhibits reduced expression with aging, and when administered, its effect in alleviating and reversing skin aging including wrinkles is excellent. Therefore, by exploiting the difference in expression, provided are a biomarker composition for measuring skin aging, capable of diagnosing skin aging; a kit; and a method of screening for skin aging alleviating agents, comprising detecting the expression level of HAPLN1 protein or HAPLN1 gene. In addition, provided are a pharmaceutical composition, cosmetic composition, or health functional food for preventing or alleviating skin aging, and a cosmetic composition or health functional food for alleviating wrinkles, each containing any one or more selected from the group consisting of HAPLN1 protein, a gene encoding the same, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 2, 2020
    Applicant: HAPLNSCIENCE INC.
    Inventors: Dae Kyong KIM, Zhicheng FU, Moon Jung BACK