Abstract: A novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.
Type:
Grant
Filed:
February 24, 1993
Date of Patent:
March 1, 1994
Assignees:
Regents of the Univ. of California, Harbor Branch Oceanographic Inst. Inc.
Inventors:
Oliver J. McConnell, Gabriel Saucy, Robert Jacobs