Abstract: Disclosed is a synergistic beverage composition for alleviating alcohol-induced oxidative stress, hepatic stress, CNS stress, veisalgia and modulating immunology parameters. The composition includes saponin glycoside, amino acid derivative and sugar or sugar alcohol as active ingredients and pH adjusting agents and flavoring agents as inactive ingredients. The calculated proportions of amino acid derivatives, Saponin glycoside and sugar or sugar alcohol in the alcohol exhibit synergistic effects, thereby alleviating oxidative stress, hepatic stress, CNS stress, veisalgia and modulating immunology parameters, which could ultimately leads to prevention of alcohol-induced damage or impairment of organs, which could be temporary or permanent.