Patents Assigned to Harvard College
  • Mode multiplexer/demultiplexer using metamaterials for optical fiber communications
    Patent number: 12659036
    Abstract: Systems, devices, and techniques for performing wavelength division multiplexing or demultiplexing using one or more metamaterials in an optical communications systems are described. An optical device may be configured to shift one or more phase profiles of an optical signal using one or more stages of metamaterials to multiplex or demultiplex wavelengths of optical signals. The optical device may be an example of a stacked design with two or more stages of metamaterials stacked on top of one another. The optical device may be an example of a folded design that reflects optical signals between different stages of metamaterials.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: June 16, 2026
    Assignees: CORNING INCORPORATED, HARVARD COLLEGE
    Inventors: Federico Capasso, Wei-Ting Chen, Paulo Clovis Dainese, Jr., Kangmei Li, Ming-Jun Li, Jaewon Oh, Jun Yang
  • Wavelength multiplexer/demultiplexer using metamaterials for optical fiber communications
    Patent number: 12405425
    Abstract: Systems, devices, and techniques for performing wavelength division multiplexing or demultiplexing using one or more metamaterials in an optical communications systems are described. An optical device may be configured to shift one or more phase profiles of an optical signal using one or more stages of metamaterials to multiplex or demultiplex wavelengths of optical signals. The optical device may be an example of a stacked design with two or more stages of metamaterials stacked on top of one another. The optical device may be an example of a folded design that reflects optical signals between different stages of metamaterials.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 2, 2025
    Assignees: CORNING INCORPORATED, HARVARD COLLEGE
    Inventors: Federico Capasso, Wei-Ting Chen, Paulo Clovis Dainese, Jr., Kangmei Li, Ming-Jun Li, Jaewon Oh, Jun Yang
  • Proteasome regulation of NF-kB activity
    Publication number: 20040097420
    Abstract: Disclosed herein is a method for regulating the activity of NF-&kgr;B in an animal comprising contacting cells of the animal with certain proteasome inhibitors.
    Type: Application
    Filed: January 28, 2003
    Publication date: May 20, 2004
    Applicant: Harvard College
    Inventors: Vito J. Palombella, Alfred L. Goldberg, Thomas P. Maniatis, Oliver Rando
  • Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
    Patent number: 5583101
    Abstract: A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contractions of skeletal muscle, which comprises administering a skeletal muscle relaxing amount to an individual in need thereof of a compound selected from the group consisting of nitroxyl ion (NO.sup.-), nitrosonium ion (NO.sup.+), nitric oxide and nitric oxide adducts or providers. This invention also is directed to stimulating the contraction of muscles in a mammal by administering an effective amount of a nitric oxide synthase inhibitor.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: December 10, 1996
    Assignees: Harvard College, Duke University
    Inventors: Jonathan Stamler, Lester Kobzik
  • Controlling nitrogen oxide concentrations to modulate skeletal muscle contraction
    Patent number: 5545614
    Abstract: A method for inhibiting or relaxing skeletal muscle contractions and for treating disease states resulting from or exacerbated by undesirable skeletal muscle contractions by administering a skeletal muscle relaxing amount of nitroxyl ion(NO.sup.-), nitrosonium ion(NO.sup.+), nitric oxide and nitric oxide adducts or providers. A process for stimulating, improving or enhancing muscle contraction in a mammal by treating the mammal with an effective amount of (i) a nitric oxide synthase inhibitor or (ii) a nitric oxide scavenger.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: August 13, 1996
    Assignees: Duke Univ., Harvard College
    Inventors: Jonathan Stamler, Lester Kobzik
  • Deactivation of antibiotic-hydrolyzing enzymes
    Patent number: 4341766
    Abstract: Method and compositions for deactivating bacterial hydrolytic enzymes which attack .beta.-lactam antibiotics.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: July 27, 1982
    Assignee: Harvard College
    Inventors: Jed F. Fisher, Jeremy R. Knowles