Patents Assigned to Harvard University, President and Fellows of Harvard College
  • Inhibition of Jun Kinase
    Publication number: 20070207137
    Abstract: A method of treating a metabolic disorder associated with insulin resistance by administering to a mammal an inhibitor of a NH2-terminal Jun Kinase (JNK), e.g., a compound or peptide which inhibits JNK1 expression or enzymatic activity.
    Type: Application
    Filed: May 1, 2007
    Publication date: September 6, 2007
    Applicant: Harvard University, President and Fellows of Harvard College
    Inventors: Gokhan Hotamisligil, Michael Karin, Lufen Chang
  • Compositions and methods for modulating NH2-terminal Jun Kinase activity
    Patent number: 7232897
    Abstract: Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH2-terminal Jun Kinase activity can lead to the reduction in weight and improve insulin sensitivity.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: June 19, 2007
    Assignee: Harvard University, President and Fellows of Harvard College
    Inventors: Gokhan S. Hotamisligil, Michael Karin, Lufen Chang