Abstract: A method for the use of light pressure to optically center a lens on a source of emitted light with submicron accuracy. In one aspect the method uses light pressure to optically center a lens on a source of emitted light, where the lens is then fixed in place. In another aspect the method uses light pressure to create an optically centered lens from a dielectric liquid on a source of emitted light, the shaped lens is then fixed to form an optically aligned permanent lens. By choosing the appropriate lens the light emitted from the source can be either focused or collimated.
Type:
Grant
Filed:
November 17, 1992
Date of Patent:
May 31, 1994
Assignee:
Harvard University
Inventors:
Mara Prentiss, Juliet A. Mervis, Adam H. Bloom, Farhad Zarinetchi
Abstract: Arrays of extended crystalline and non-crystalline structures are created using light beams coupled to microscopic polarizable matter. Polarizable matter adopts the pattern of an applied, patterned light intensity distribution. Further, polarizable matter itself scatters applied light, resulting in production of a stable, bound configuration of that matter. Alternatively, polarizable matter can simultaneously adopt the pattern of an applied patterned light intensity while the incident light scattered by the matter itself acts further to organize the matter. Dielectric, semiconductor, metal, molecular, atomic and biological matter can be organized using light to fabricate numerous devices including mechanical and optical filters, self-organizing Bragg lasers, templates for epitaxy, photonic semiconductors, optical components including holograms and diffractive optical elements as well as two dimensional membranes of living biological cells.
Type:
Grant
Filed:
October 8, 1991
Date of Patent:
September 14, 1993
Assignee:
President and Fellows of Harvard University and Rowland Institute
Inventors:
Michael M. Burns, Jean-Marc Fournier, Jene A. Golovchenko
Abstract: This invention relates to the use of diethylcarbamazine (DEC), its analogs, homologs, and pharmaceutically acceptable salts thereof as an antiviral agent. This invention further relates to the use of DEC in in vivo diagnosis to increase antibodies to a particular disease; to the use of DEC in in vitro serologic assays to increase efficacy; and to the use of DEC as a vaccine adjuvant.
Abstract: 7.beta.-Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxyli c acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.
Abstract: 1-Benzyl (or substituted benzyl)-3.beta.-[4(S)-aryloxazolidin-2-one-3-yl]-4.beta.-(2-arylvinyl)azet idin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic .beta.-lactam antibiotics.