Abstract: A controlled and closed agricultural system includes a growing space and an air handling system having an enthalpy wheel and cooling coil. The enthalpy wheel is capable of transferring sensible and latent heat and is positioned in and rotatable through a recirculating air duct and an outside air duct. The recirculating air duct is in fluid connection with the growing space and one or more recirculation fans, while the outside air duct is in fluid connection with one or more outside air fans positioned to cause outside air to flow countercurrent to recirculating air. A cooling coil is positioned within the recirculating air duct, downstream of and in series with the enthalpy wheel. The cooling coil circulates a heat transfer fluid to remove additional heat from the recirculating air.