Patents Assigned to HC-PHARMA AG
  • Process for the preparation of sofosbuvir
    Patent number: 10112967
    Abstract: A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived from Candida Antarctica to obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 30, 2018
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Giuseppe Pallanza, Marco Baratella, Graziano Castaldi, Marta Castaldi
  • Sofosbuvir in crystalline form and process for its preparation
    Patent number: 9845335
    Abstract: Sofosbuvir in crystalline Form ?, process for its production and use in pharmaceutical compositions.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: December 19, 2017
    Assignee: HC-PHARMA AG
    Inventors: Mauro Gaboardi, Marta Castaldi, Graziano Castaldi, Sara Helmy