Abstract: A check processing system detects fraud in real-time by comparing data from presented checks against known check data stored in a Global Check Register (GCR). The system analyzes check images and extracts payee information. Instead of reviewing the entire check for each item of information, a region of interest (ROI) is investigated. The use of an ROI defeats a type of fraud wherein original payee information is placed on the memo line of the check with the payee information changed to a fraudulent payee name. By validating the presented check data against known data points, the system can identify discrepancies and potential fraud in real-time, generating events and notifications for bank employees to take appropriate action in a timely manner.