Abstract: A container with a centrally located, integrally formed non-coring and non-leaking piercing site for use with sterile instruments. A double dome construction is employed to permit needle penetration without coring by the needle and provide sealing between the container and the needle. Provision is also made to insure sealing when a larger diameter plastic needle is employed. In another embodiment there is provided a container with a non-coring piercing site and a separate sealing cover.

Abstract: Sterile solution delivery and venting devices for use with multi-dose sterile solution packages are disclosed. The devices include a positive acting, normally closed check valve which opens to express solution from the package when squeezing pressure is applied and which automatically closes when the pressure is released. A hydrophobic filter is included to sterilize the replacement air which enters the package upon release of the squeezing pressure.

Abstract: A flow regulator for use in an I.V. administration arrangement which establishes and maintains the rate of liquid flow regardless of changes in head which may occur. The regulator utilizes a diaphragm controlled orifice and a bypass with a valve to establish the flow rate. The diaphragm adjusts the effective orifice opening to maintain constant the flow selected by the valve.

Abstract: A container with integrally formed non-coring and non-leaking piercing site for use with sterile instruments. A double dome construction is employed to permit needle penetration without coring of the needle and provide sealing between the container and the needle. Provision is also made to insure sealing when a larger diameter plastic needle is employed.

Abstract: A single use vial is provided in clusters of five or two times five separably joined vials. The vials are molded and filled with a medicated or non-medicated solution and each vial is provided with a converging, planar front wall. The vials include an integral dispensing nozzle, having a conduit which can be exposed by removing a twist off closure. A common separation strip joins the facing side of adjacent vials in the cluster but not the twist off closures. The angle of convergence of the front wall is designed to elevate the conduit above the solution level when the front wall is placed upon a horizontal surface to prevent unwanted dripping prior to use.