Abstract: An integrated clinical tele-informatics based system that provides outpatient health care delivery, self-care services, clinical communications and information, and clinical practice management services. The system retrieves and analyzes sign and symptom data of patients according to a plurality of case management rules, generates a patient information and develops a therapeutic program in response to the information. The therapeutic program is regularly updated based upon system monitoring of the patient's condition. The system provides clinical management functional tools that alert a Personal Health Advisor when the data of at least one patient exceeds predefined medical parameters, triage clinical activity of volumes of patients based on the patient data, transform the data into clinical practice management information, and generate clinical practice management information reports of summarized text, numerical representations, and/or graphical representations.