Patents Assigned to Health Research, Inc.
-
Publication number: 20210008194Abstract: Disclosed is an adapted Madin-Darby canine kidney cell line capable of suspension culture in the absence of serum, and a chemically-defined medium for culture of the adapted MDCK cell line. Further disclosed are culture methods for growing the adapted MDCK cell line and methods for producing a vaccine from the adapted MDCK cell line grown in the chemically-defined medium.Type: ApplicationFiled: September 28, 2020Publication date: January 14, 2021Applicants: NATIONAL HEALTH RESEARCH INSTITUTES, FUJIFILM IRVINE SCIENTIFIC, INC.Inventors: Jenny BANG, Hsiao-Tzu NI, Alan Yung-Chih HU, Tsai-Chuan WENG
-
Publication number: 20200323972Abstract: Provided is an immunogenic composition including a peptide, wherein consecutive amino acids of the peptide include at least amino acids 186-193 of SEQ ID NO:1 and one or more adjuvants. In an example, the peptide is covalently linked to an amino acid sequence including SEQ ID NO:2.Type: ApplicationFiled: June 3, 2020Publication date: October 15, 2020Applicant: Health Research, Inc.Inventor: Yi-Pin LIN
-
Patent number: 10786564Abstract: Disclosed is an adapted Madin-Darby canine kidney cell line capable of suspension culture in the absence of serum, and a chemically-defined medium for culture of the adapted MDCK cell line. Further disclosed are culture methods for growing the adapted MDCK cell line and methods for producing a vaccine from the adapted MDCK cell line grown in the chemically-defined medium.Type: GrantFiled: October 31, 2016Date of Patent: September 29, 2020Assignees: NATIONAL HEALTH RESEARCH INSTITUTES, FUJIFILM IRVINE SCIENTIFIC, INC.Inventors: Jenny Bang, Hsiao-Tzu Ni, Alan Yung-Chih Hu, Tsai-Chuan Weng
-
Patent number: 10738129Abstract: Provided are survivin specific antibodies, nucleic acids encoding the antibodies and methods for treating tumors comprising survivin-expressing cells by administration of the antibodies. The antibody compositions were found to be effective in inhibiting the growth of tumors.Type: GrantFiled: December 27, 2018Date of Patent: August 11, 2020Assignee: Health Research, Inc.Inventors: Robert A. Fenstermaker, Michael J. Ciesielski
-
Patent number: 10738119Abstract: Provided are methods and compositions for a combination therapy for liver disorders such as hepatocellular carcinoma. Also provided is a method for determining the effectiveness of therapy involving tyrosine kinase inhibitors such as sorafenib. The method comprises determining the status of PD-1 on T cells, and based on a change in the level of PD-1 on certain cells, a determination of the effectiveness of the tyrosine kinase, and an indication for a combination therapy comprising a lower dose of tyrosine kinase inhibitor and a PD-1 inhibitor can be made.Type: GrantFiled: February 18, 2015Date of Patent: August 11, 2020Assignee: Health Research, Inc.Inventor: Yasmin Thanavala
-
Patent number: 10695413Abstract: Provided is an immunogenic composition including a peptide, wherein consecutive amino acids of the peptide include at least amino acids 186-193 of SEQ ID NO:1 and one or more adjuvants. In an example, the peptide is covalently linked to an amino acid sequence including SEQ ID NO:2.Type: GrantFiled: December 21, 2018Date of Patent: June 30, 2020Assignees: HEALTH RESEARCH, INC., LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTERInventors: Yi-Pin Lin, Kaspars Tars
-
Patent number: 10624881Abstract: Provided are methods for inducing apoptosis of cells using quinolinol compounds. Combinations of quinolinol compounds can be used in the methods. Combinations of one or more quinolinol compound and one or more inhibitors of cell growth arrest, e.g., Nutlin3a, can also be used in the methods. Also provided are compositions comprising of one or more quinolinol compound and one or more pharmaceutically acceptable carrier. The compositions can comprise one or more quinolinol compound, one or more pharmaceutically acceptable carrier, and one or more inhibitors of cell growth arrest, e.g., Nutlin3a.Type: GrantFiled: October 12, 2016Date of Patent: April 21, 2020Assignee: Health Research, Inc.Inventor: Xinjiang Wang
-
Patent number: 10568963Abstract: A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.Type: GrantFiled: August 3, 2012Date of Patent: February 25, 2020Assignees: HEALTH RESEARCH, INC., HE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
-
Publication number: 20200057053Abstract: The technology described herein is directed to methods of treating and diagnosing bronchial premalignant lesions, e.g. by determining the lesion subtype using one or more biomarkers described herein.Type: ApplicationFiled: August 20, 2019Publication date: February 20, 2020Applicants: TRUSTEES OF BOSTON UNIVERSITY, HEALTH RESEARCH, INC.Inventors: Jennifer E. Beane-Ebel, Avrum E. Spira, Marc Lenburg, Mary E. Reid, Sarah Mazzilli
-
Patent number: 10487362Abstract: Provided are compositions and methods for detecting in a sample the presence or absence, and/or the amount, of a small nucleolar RNA (snoRNA) HBII-52, also known as SNORD115. The compositions and methods are useful in diagnosis, prognosis, therapy recommendations, therapy, and monitoring of therapy for individuals who have a disorder that is positively correlated with elevated HBII-52, such as cancer, and particularly for prostate cancer. Kits containing primers for detecting and/or amplifying HBII-52 from a biological sample are provided. The disclosure includes a method for monitoring an individual undergoing therapy for a disorder associated with HBII-52 expression, a method for identifying an individual as a candidate for therapy with an antagonist of 5-HT2cR, and a method for therapy by administering to a subject a therapeutically effective amount of an antagonist of 5-HT2cR.Type: GrantFiled: January 9, 2014Date of Patent: November 26, 2019Assignee: Health Research, Inc.Inventors: Barbara Foster, Steven J. Seedhouse, Jason Kirk
-
Patent number: 10478086Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor.Type: GrantFiled: March 17, 2016Date of Patent: November 19, 2019Assignee: HEALTH RESEARCH, INC.Inventors: Gerwin Schalk, Peter Brunner, William G. Coon, Adriana De Pesters
-
Patent number: 10478477Abstract: Provided are compositions and methods for prophylaxis and/or therapy of ErbB1-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase D (PEPD) proteins. The methods include prophylaxis and/or therapy of ErbB1-positive cancer by administering a PEPD to an individual who has or is at risk for developing ErbB1-positive cancer.Type: GrantFiled: August 20, 2015Date of Patent: November 19, 2019Assignee: Health Research, Inc.Inventors: Yuesheng Zhang, Lu Yang, Yun Li, Arup Bhattacharya
-
Publication number: 20190293660Abstract: Provided is a method of detecting the presence of an anti-Zika virus (ZIKV) antibody in a sample, including contacting a sample with a suspension having a plurality of microspheres wherein individual microspheres are conjugated to a peptide and the peptide includes a ZIKV peptide selected from the group including ZIKV NS1, ZIKV NS5, and ZIKV envelope protein, forming a first incubated suspension by incubating said sample with said suspension to permit binding of anti-ZIKV antibodies present in the sample to said microspheres, forming a second incubated suspension by contacting said first incubated suspension with an anti-ZIKV antibody detecting-reagent to permit binding of the anti-ZIKV antibody detecting reagent to said microspheres, removing from the second incubated suspension anti-ZIKV antibody detecting-reagent molecules that are not bound to said microspheres, and detecting the presence of anti-ZIKV antibody detecting-reagent molecules in the second incubated suspension.Type: ApplicationFiled: June 10, 2019Publication date: September 26, 2019Applicants: Health Research, Inc., The Board of Regents of The University Of Texas SystemInventors: Susan J. WONG, Pei-Yong SHI
-
Patent number: 10393746Abstract: The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (IL-8), Tumor necrosis factor alpha (TNF-?) and soluble tumor necrosis factor-? receptor 1 (sTNFR1), and may further include testing for prostate serum antigen (PSA). Use of these markers in combination provides tests that are more sensitive and specific than PSA in differentiating benign versus malignant prostate disease and/or localized CaP versus metastatic CaP and show that the specificity and sensitivity of a PSA-based CaP diagnosis can be significantly enhanced by measuring IL-8, TNF-? and sTNFR1.Type: GrantFiled: May 30, 2018Date of Patent: August 27, 2019Assignee: Health Research, Inc.Inventors: Kailash Chadha, Willie Underwood, Austin Miller
-
Patent number: 10366780Abstract: A predictive system and method for using a physician's existing patient database to more effectively and efficiently identify potential candidates for medical treatments or clinical research trials. The system and method includes an automated three-tiered qualification process using information about a specific medical treatment received from a company looking for potential candidates for the medical treatment wherein potential candidates are initially prequalified by comparing the information about the medical treatment to the information contained in a physician's patient database. The potential candidates that are identified by the first tier of the qualification process then answer additional questions from a patient screening survey. Finally, additional questions from a physician consultation questionnaire are completed by the referring physician's office.Type: GrantFiled: January 24, 2014Date of Patent: July 30, 2019Assignee: ELLIGO HEALTH RESEARCH, INC.Inventors: Thomas Dorsett, Tushar Jain
-
Patent number: 10344052Abstract: Provided are peptides, fusion proteins which include the peptide sequences, compositions comprising such peptides and fusion proteins, and methods for making and using the compositions. The peptides are characterized as being able to selectively bind to components of the endothelial compartment that are exposed during the period between 1 and 7 days after androgen deprivation.Type: GrantFiled: March 14, 2014Date of Patent: July 9, 2019Assignee: Health Research, Inc.Inventors: Gary Smith, Ryan Willard
-
Publication number: 20190201516Abstract: Provided is an immunogenic composition including a peptide, wherein consecutive amino acids of the peptide include at least amino acids 186-193 of SEQ ID NO:1 and one or more adjuvants. In an example, the peptide is covalently linked to an amino acid sequence including SEQ ID NO:2.Type: ApplicationFiled: December 21, 2018Publication date: July 4, 2019Applicant: Health Research, Inc.Inventors: Yi-Pin LIN, Kaspars TARS
-
Patent number: 10316072Abstract: A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170 protein comprises an NF-?B-activating domain of Flagellin and an ATP-binding domain truncated Grp170. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.Type: GrantFiled: October 26, 2017Date of Patent: June 11, 2019Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, HEALTH RESEARCH, INC.Inventors: Xiang-Yang Wang, Xiaofei Yu, John R. Subjeck
-
Publication number: 20190160028Abstract: Provided is a method of inhibiting viral replication, including contacting one or more cells that has been infected or contacted with a flavivirus with an effective amount of niclosamide, temoporfin, nitazoxanide, tizoxanide, erythrosin B, methylene blue. Contacting one or more cells that have been infected with a flavivirus may include administering the compound to a mammal, a human, or other subject. The flavivirus may be Dengue virus serotype 1, Dengue virus serotype 2, Dengue virus serotype 3, Dengue virus serotype 4, yellow fever virus, West Nile virus, Zika virus, Japanese encephalitis virus, tick-born encephalitis virus, Powassan virus, St. Louis encephalitis virus, or other flavivirus.Type: ApplicationFiled: June 23, 2017Publication date: May 30, 2019Applicants: HEALTH RESEARCH, INC., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVInventors: Hongmin LI, Laura D. KRAMER, Zhong LI, Ruili HUANG, Menghang XIA
-
Patent number: 10297169Abstract: An intubation simulator and method are disclosed. The simulator includes a human mannequin with a mouth and a sensorized conduit. A glide scope disposed in the sensorized conduit. A first manipulator and a second manipulator are connected to the glide scope by way of a linkage. A method for simulating intubation is disclosed, where an intubation simulator is provided, computer-based instructions are provided to cause a first and second manipulator of the simulator to simulate the haptic environment of a human through the glide scope. A sensorized conduit of the simulator is used to sense a position of a tracheal tube being placed during the simulated intubation.Type: GrantFiled: January 5, 2015Date of Patent: May 21, 2019Assignee: Health Research, Inc.Inventors: Khurshid Guru, Ashirwad Chowriappa