Patents Assigned to Health Research, Inc., Roswell Park Division
  • Patent number: 7402659
    Abstract: The present invention provides Thymic Stromal Lymphopoietin Receptor (TSLPR) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TSLPR polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TSLPR polypeptides.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: July 22, 2008
    Assignees: Whitehead Institute for Biomedical Research, The Government of the United States of America, Health Research Inc., Roswell Park Division, University of Washington
    Inventors: Akhilesh Pandey, Katsutoshi Ozaki, Heinz Baumann, Steven D. Levin, Andrew G. Farr, Warren J. Leonard, Harvey F. Lodish
  • Patent number: 7129225
    Abstract: The present invention provides a method for protecting against or treating hearing loss in a subject. This method involves administering an effective amount of a protein tyrosine kinase inhibitor to the subject to protect against or to treat hearing loss.
    Type: Grant
    Filed: October 19, 2002
    Date of Patent: October 31, 2006
    Assignees: The Research Foundation of State University of New York, Health Research Inc. (Roswell Park Division)
    Inventors: Thomas Nicotera, Donald Henderson, David G. Hangauer, Jr.
  • Patent number: 7094561
    Abstract: The present invention relates to methods of monitoring the menstrual cycle and/or the first half of pregnancy in a female by assessing the adhesion of lymphocytes from the female to uterine or lymphoid histological tissues from a pregnant animal or an animal that has been treated with gestational hormones. The method can be used to determine the ability of the lymphocyte donor's immune system to recognize and respond to an environment suitable for sustaining a pregnancy.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: August 22, 2006
    Assignees: University of Guelph, Health Research, Inc., Roswell Park Division
    Inventors: Barbara Anne Croy, Sharon S. Evans
  • Patent number: 4918056
    Abstract: Novel arabinopyranosyl nucleoside derivatives having the heterocyclic moiety and fluorine at the 2' position of the sugar ring (pyranose configuration), which have antitumor, antiviral and antimicrobial properties, are prepared by condensation of a pyrimidine, purine or 1,3-oxazine base with an acylated 2-deoxy-2,2-difluoro-D-arabinopyranoside and/or acylated 2-deoxy-2-bromo-2-fluoro-D-arabinopyranoside.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: April 17, 1990
    Assignee: Health Research, Inc. (Roswell Park Division)
    Inventors: Miroslav V. Bobek, Seung-Ho An, Ralph J. Bernacki
  • Patent number: 4658017
    Abstract: A process for the large scale purification of human fibroblast interferon produced by human diploid fibroblasts under superinduction conditions characterized by a sequence of four chromatographic steps namely:(1) separation on CM-agarose;(2) separation on ConA-agarose;(3) separation on phenyl-agarose; and(4) elimination of ethylene glycol using CM-agarose which process yields a final overall recovery not less than 60% of the crude interferon starting material and having a specific activity not less than 1.times.10.sup.8 units per mg of protein.
    Type: Grant
    Filed: February 14, 1984
    Date of Patent: April 14, 1987
    Assignee: Health Research, Inc. (Roswell Park Division)
    Inventors: Wlodzimierz E. Dembinski, Eugene Sulkowski
  • Patent number: 4654301
    Abstract: An improved assay procedure for quantitatively detecting LDH.sub.k isozyme in human serum is provided which utilizes previously known electrophoretic gel separation procedures combined with an improved staining method wherein the staining solution has a constant temperature of about 37.degree. C. and a pH of about 8.0, and is contacted with the gel matrix for at least 3 hours in the absence of oxygen and light. This improved assay procedure may be used as an adjunct to other procedures for diagnosing the presence of primary cancer, as a post-operative indicator of metastatic cancer and in monitoring the success of cancer therapy.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: March 31, 1987
    Assignee: Health Research, Inc. (Roswell Park Division)
    Inventors: Garth R. Anderson, Kenneth F. Manly, Arnold Mittelman
  • Patent number: 4622392
    Abstract: This invention relates to cytotoxic compounds. More particularly, this invention relates to conjugates of antitumor agents, and thiophospholipids exhibiting enhanced antitumor activity to methods for producing such compounds and to pharmaceutical compositions containing cytotoxically effective amounts of such compounds as a primary effective ingredient.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: November 11, 1986
    Assignee: Health Research Inc. (Roswell Park Division)
    Inventors: Chung I. Hong, Charles R. West