Abstract: Provided is a polynucleotide encoding a respiratory syncytial virus (RSV) variant having an attenuated phenotype comprising a modified RSV genome or antigenome that encodes a mutant RSV protein P that differs from a parental RSV protein P at one or more amino acid residues. In some embodiments, the polynucleotide is recombinant. The invention also relates to methods of vaccinating an animal with the RSV variant or a pharmaceutical composition containing the RSV variant or inducing an immune response by administering the RSV variant to an animal, and further relates to methods of producing an RSV variant vaccine. In some embodiments, the animal is a human.

Abstract: Compositions comprising bile acids or their salts and methods of use thereof for the treatment of residual lesions of vascular anomalies.

Abstract: The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants.

Abstract: A method is disclosed for automating creation of an account to access to a plurality of cloud based platforms, comprising receiving an intake request; determining whether the account is requested on a first cloud platform or a second cloud platform; determining whether an environment is requested; in response to a determination that an environment is requested, creating a created environment; in response to a determination that an environment is not requested, associating an existing environment with the account; in response to a determination that an environment is requested and a determination that the account is requested on the first cloud platform, creating network handlers; creating a workspace and a repository; creating vault secrets; in response to a determination that the account is requested on the first cloud platform, and tagging at least one resource associated with the account with a resource tag.

Abstract: Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also described is the production and use of protease inhibitor enriched HDL particles, as well as AlAT-peptide-enriched HDL particles, and their use in various therapeutic contexts.

Abstract: The present invention relates to a separation device or system using a separation membrane, as a method of separating impurity ions other than hypochlorous acid from an aqueous solution containing hypochlorous acid as a main component, and provides a solution containing hypochlorous acid as a main component, having more excellent storage stability.

Abstract: Disclosed are methods of isolating a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous APCs of the patient to present the mutated amino acid sequence; co-culturing autologous T cells of the patient with the autologous APCs that present the mutated amino acid sequence; selecting the autologous T cells; and isolating a nucleotide sequence that encodes the TCR from the selected autologous T cells, wherein the TCR has antigenic specificity for the mutated amino acid sequence encoded by the cancer-specific mutation. Also disclosed are related methods of preparing a population of cells, populations of cells, TCRs, pharmaceutical compositions, and methods of treating or preventing cancer.

Abstract: A graphene oxide-based membrane There is provided a graphene oxide-based membrane comprising a substrate and a plurality of layers of single-layered graphene oxide formed on the substrate, each of the plurality of layers of single-layered graphene oxide is functionalised by at least one diamine functional group, wherein interlayer spacing between two adjacent layers of single-layered graphene oxide is ? 10 Å. The membrane may be comprised in an electrocapacitive unit. There is also provided a method of forming the membrane.

Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.

Abstract: A moving bed has a fixed bed part as a resting area for the head and upper body of a person, and a longitudinally moving bed part as a resting area for the buttocks and legs of a person. The bed has a first bed frame in the form of a stationary fixed frame that extends as a stationary longitudinal frame over the entire length of the bed and on which the upper, fixed bed part is formed. The bed has a second bed frame as a moving frame, which forms the lower longitudinally moving bed part; the moving frame is held to the fixed frame so that it can move longitudinally. A motor drive is mounted between the fixed frame and the moving frame, and by this motor drive, the moving frame may be moved alternatingly back and forth relative to the fixed frame in a predetermined longitudinal section.

Abstract: Methods and systems to stratify risks for adverse health outcomes include aggregating data sets culled over a predetermined period of time; adjusting at least two variables within the aggregated data sets; and executing a regression analysis to identify an average causal effect between aggregated variables against at least one particular adverse health outcome.

Abstract: Oxidative stress is implicated in neurodegenerative diseases such as Alzheimer's disease, and has been extensively studied as a potential target for therapeutic intervention. The present disclosure discloses a method for reducing free radicals in a mammal, the method comprises administering a composition containing an effective amount of Baillonella toxisperma extract to a mammal to reduce free radicals in the mammal. Specifically, the present disclosure demonstrates how extracts and flavonoids fractions of Baillonella toxisperma provide antioxidant and neuroprotective benefits and prevent oxidative stress in mammals.

Abstract: A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, a first adhesive layer disposed on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a second adhesive layer disposed over the first adhesive layer and configured to provide a sealing engagement between the body and the urethral meatus, wherein the second adhesive layer is removable from the first adhesive layer.

Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

Abstract: A system and methods are provided in which an artificial intelligence inference module identifies targeted information in large-scale unlabeled data, wherein the artificial intelligence inference module autonomously learns hierarchical representations from large-scale unlabeled data and continually self-improves from self-labeled data points using a teacher model trained to detect known targets from combined inputs of a small hand labeled curated dataset prepared by a domain expert together with self-generated intermediate and global context features derived from the unlabeled dataset by unsupervised and self-supervised processes. The trained teacher model processes further unlabeled data to self-generate new weakly-supervised training samples that are self-refined and self-corrected, without human supervision, and then used as inputs to a noisy student model trained in a semi-supervised learning process on a combination of the teacher model training set and new weakly-supervised training samples.

Abstract: In accordance with one embodiment of the present disclosure, a method includes generating a plurality of icons, wherein each icon has a target frequency unique from each other, receiving brain activity data based on an epoch, generating a reference signal based on the epoch, calculating correlation coefficients between the brain activity data and the reference signal, wherein the correlation coefficients are calculated in a window that is within ±0.5 Hz of the target frequencies, including endpoints, determining a confidence score based on the correlation coefficients and the epoch, and determining a selected icon among the plurality of icons based on the correlation coefficients in response to the confidence score surpassing a threshold confidence score.

Abstract: A system includes video cameras arranged to monitor a vulnerable person, and a processor system that receives video frames from the video cameras, the processor system comprising a processor and a non-transitory, computer-readable storage medium having machine instructions executed by the processor. The processor detects and identifies objects in a current received video frame, classifies an identified object as the person by applying a facial recognition algorithm that identifies the person, determines a posture of the person by identifying joints, limbs, and body parts, and their respective orientations to each other and to a plane, and immediately discards the current video frame. The processor then determines a change in motion, of the person, between the current received video frame and one or more prior received video frames, and, based on the determined posture and the change in motion, determines that the person has experienced a defined event.