Abstract: An IL-11 binding receptor capable of binding to IL-11 and inhibiting IL-11 mediated signalling is disclosed. Also disclosed are compositions comprising the IL-11 binding receptor and methods using the IL-11 binding receptor.

Abstract: An extract of Lilium hansoni Leichtlin ex Baker, according to the present invention, exhibits a whitening effect by inhibiting the expression of tyrosinases and reducing the total amount of melanin, reduces wrinkles and improves skin elasticity by promoting collagen synthesis of fibroblasts in the skin and inhibiting the activity of collagenases, exhibits an effect of anti-glycation that inhibits glycation, exhibits a skin moisturization effect by promoting the synthesis of hyaluronic acid, exhibits an effect of improving skin texture by reducing skin roughness, and exhibits effects of irritation relief and relief of stinging, itching, burning sensations and the like, thereby being usable in the preparation of cosmetic products, pharmaceuticals and foods.

Abstract: A height-adjustable support for supporting various bodily limbs over a wide range of limb positions, and in hospital rooms, doctors' offices, or other compact environments. The device permits a medical procedure to be performed by a single person while the device supports the limb. The device includes a rigid base, at least one support mounted to the base to extend therefrom, and a cradle mounted on the support, the cradle defining a surface configured to support a limb of a patient. The supports may be adjustable in length, and the cradle may be adjustable in angular position. The cradle may be U-shaped or otherwise concavely-shaped, and may be linked with a cushioning material. A cover may be provided, and the cover and/or cradle may be configured with complementary fasteners for releasably attaching the cover to the cradle, so that the cover may be discarded after each use.

Abstract: Stress management apparatus includes a wearable device having one or more physiological sensors operable to be engaged with a body of a user. One or more processors communicatively coupled with the wearable device having a memory storing instructions when executed operable to: detect one or more physiological indicators of stress; suggest a stress intervention to the user; monitor compliance with the stress intervention; and track a reduction of the one or more physiological indicators of stress.

Abstract: The present application provides a composition for inducing chondrogenesis comprising an Wnt antagonist and a pharmaceutically acceptable carrier. The present application also provides a method for inducing chondrogenesis comprising administering an Wnt antagonist and a pharmaceutically acceptable carrier to a subject. The present application further provides a method for treating a cartilage-related disease comprising administering a therapeutically effective amount of an Wnt antagonist and a pharmaceutically acceptable carrier to a subject.

Abstract: The present disclosure relates to a next generation DNA sequencing method and use for accurate and massively parallel quantification of one or more nucleic acid targets, for example in large volumes of unpurified sample material. More particularly, the present disclosure is related to a method and a kit comprising probes for detecting and quantifying genetic targets in complex samples. The disclosed embodiments includes one or more target-specific nucleic acid probes per genetic target (left probe and right probe) and a bridge oligo or bridge oligo complex.

Abstract: The present invention disclosure relates to a next generation DNA sequencing method and use for accurate and massively parallel quantification of one or more nucleic acid targets, for example in large volumes of unpurified sample material. More particularly, the invention is related to a method and a kit comprising probes for detecting and quantifying genetic targets in complex samples. The invention includes one or more target-specific nucleic acid probes per genetic target and a bridge oligo or bridge oligo complex.

Abstract: A composite nonwoven sheet material comprising a reinforcement layer comprising mainly reinforcement filaments, a pulp layer comprising mainly pulp fibers, and a surface layer comprising mainly microfibers, wherein the pulp layer is interposed between the reinforcement layer and the surface layer, and wherein the pulp fibers are entangled with the reinforcement filaments and the microfibers. A process of producing a composite nonwoven sheet material, comprising: forming a fibrous web comprising a reinforcement layer comprising mainly reinforcement filaments, a pulp layer comprising mainly pulp fibers, and a surface layer comprising mainly microfibers, wherein the pulp layer is interposed between the reinforcement layer and the surface layer; and hydroentangling the fibrous web to form the composite nonwoven sheet material.

Abstract: An absorbent article for absorption of body fluids, including an absorbent member that includes at least one plant protein based absorbent material obtainable by a method including the steps of i. providing a mixture or suspension including a liquid and a plant protein, wherein the plant protein is insoluble in the liquid, ii. acylating the plant protein by adding an acylating agent thereto, and iii. obtaining the plant protein based absorbent material.

Abstract: The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

Abstract: This disclosure generally relates to system design for a handheld ultrasound imaging system, which may generate an ultrasound image of tissue. The handheld ultrasound imaging system may comprise: an ultrasound transducer array to generate ultrasound waves comprising a wavelength; a processor coupled to the ultrasound transducer array, the processor configured with instructions that when executed cause the processor to: receive ultrasound data derived from the ultrasound transducer array and generate the plurality of ultrasound images, the plurality of ultrasound images comprising an axial resolution capable of resolving the tissue structure no more than the wavelength, and output the plurality of ultrasound images.

Abstract: Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 ?m and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.

Abstract: An editor application configured for setting up at least one evaluation data structure is described, wherein each evaluation data structure is configured for evaluating a corresponding specific motion pattern in a sequence of image data structures. Each evaluation data structure comprises a ML model artifact configured for determining, based on input data comprising key data elements provided for at least one image data structure, class labels for each image data structure, said class labels identifying at least one of: at least one motion phase of the specific motion pattern, at least one evaluation point of the specific motion pattern. A key data element indicates a respective position of a landmark in the image data structure.

Abstract: A medical expense document management system including a document management server is disclosed. The server is configured to receive from a user client device an image of a medical document, convert the image into a plurality of text elements using OCR, and determine a source of the document. The server is also configured to retrieve data detectors from a database, each data detector associated with a data type anticipated to be in the document, each detector having at least one identifier, at least one direction describing a potential relative direction of a text element having a label associated with the detector, and at least one validation criteria. The server is also configured to identify a potential descriptor by comparing each text element with the at least one identifier, determine if the text element pointed to by one of the directions meets the validation criteria, and store the validated text element.

Abstract: Methods of repairing a partially double-stranded DNA fragment are provided. In some embodiments, the methods comprise (a) contacting the partially double-stranded DNA fragment with one or more primers of a primer population, wherein the partially double-stranded DNA fragment comprises a 3? overhang and the primer population comprises a random target-hybridizing sequence; (b) extending one or more primers of the primer population along the DNA fragment using a DNA polymerase, thereby producing one or more extended primers annealed to the DNA fragment; and (c) ligating the 3? end of one or more extended primers to the 5? end of an extended primer or a strand of the partially double-stranded DNA fragment, thereby providing a repaired DNA fragment.

Abstract: The present invention provides a laundry sheet in which at least one laundry component is distributed inside a matrix formed from a water-soluble polymer, which is a polyvinyl alcohol or a polyvinyl alcohol-based polymer, and the laundry sheet has (i) a foamability of 0.5-0.9 (g/cm3) or (ii) a drape stiffness of 3.5-7.5 cm.

Abstract: A pneumatic physiotherapy apparatus with a unique structure comprising a wrap and an operating unit: wherein a wrap includes at least an outer wrap, an inner component housing, and an inner air bladder set; the operating unit is fixed to the outer wrap; the operating unit is also connected to the inner component housing; and the inner component housing is hidden inside the wrap. In addition, the apparatus can also have the operating unit operate an inflation motor and an integrated control board. The apparatus uses an inner air bladder set wherein each air bladder is inflatable. The apparatus can also contain a solenoid valve and a pressure detection valve. This design hides bulky components and eliminates connecting brackets. Therefore, this apparatus is a unique structure that allows a user to experience the extraordinary beauty of pneumatic physiotherapy apparatuses.

Abstract: Antibodies that bind SARS-CoV Spike protein, SARS-CoV-2 Spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.

Abstract: Methods, apparatus and systems for managing subrogation cases are described.