Abstract: Regional, tumor-targeted, cytotoxic therapy, such as D2C7-immunotoxin (D2C7-IT), not only specifically target and destroy tumor cells, but in the process initiate immune events that promote an in situ vaccine effect. The antitumor effects are amplified by immune checkpoint blockade which engenders a long-term systemic immune response that effectively eliminates all tumor cells.

Abstract: A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and bottom gripping wings face each other to grip the annulus between them and the second top and bottom gripping wings face each other to grip the annulus between them.

Abstract: A mesh network includes a source node and non-source nodes. The source node generates geofenced message information defining a geofenced message for one or more non-source nodes within a geofence. The source node transmits the geofenced message information for reception by a non-source node within a communication range of the source node. The non-source node, responsive to receiving the geofenced message information, transmits the geofenced message information for reception by other non-source nodes within a communication range of the non-source node. Based on the location of the non-source node being within the geofence, the non-source node presents the geofenced message. Based on the location of the non-source node being within the geofence, the non-source node does not presents the geofenced message.

Abstract: A height adjustment mechanism for exercising apparatus includes a first frame body and a second frame body being slidable relative to the first frame body in an adjusting direction. The second frame body has a series of positioning holes. A pressing member is disposed at one side of the first frame body for tightening or loosening the second frame body. A slidable block is limitedly movable along the first frame body in the adjusting direction. A pin member is received in the slidable block and operable to be engaged in a selected one of the positioning holes so that movement of the second frame body causes movement of the slidable block within a limited range. When the slidable block moves toward bottom of the limited range, the pressing member is pulled inward by at least one connecting arm to a tightening position to clamp the second frame body.

Abstract: The present disclosure provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to a cell comprising an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR) or a T cell receptor (TCR)) and a dominant negative Fas polypeptide. In certain embodiments, the cells are antigen-directed and exhibit enhanced cell persistence, and enhanced anti-target treatment efficacy.

Abstract: A dental wrap is provided. The dental wrap includes an adhesive layer and a backing layer, which is characterized in that it does not contain an active ingredient. The present invention can improve the user's feeling of use by applying various flavors that were difficult to use in the tooth whitening agent.

Abstract: A cosmetic composition and method for promoting skin exfoliation are disclosed. Specifically, a cosmetic composition which includes a calcium-binding substance and a substance that changes protein structure, and thus, has an excellent exfoliation effect compared to the conventional effective raw material even at a weakly acidic-neutral pH, and has low skin irritation, and maximizes exfoliating ability through a combination of raw materials, thereby increasing efficiency and reducing side effects.

Abstract: Described herein is a method for removing unwanted calcium hydroxylapatite or another calcium salt deposited by injection cutaneously in a subject, the method comprises administering an effective amount of a composition containing sodium thiosulfate to the deposited calcium hydroxylapatite or another calcium salt using a therapeutically effective regimen to diminish and or remove the amount of unwanted calcium hydroxylapatite or another calcium salt.

Abstract: A dispenser part includes a first injection molded plastic component part with an associated first mating surface along a first edge; a second injection molded plastic component part having an associated second mating surface; a seam formed by the first mating surface and the second mating surface during injection moulding for joining the first component part and the second component part to define a dispenser part. A transverse cross section of the seam includes at least one step and at least one contact surface intermediate an inner and an outer surface of the dispenser part.

Abstract: Methods are provided for expediting screening of medical data. In some methods, medical records are obtained from a requester. Each medical record includes a digitized image of a body region of a patient. For each image, a processor is used to: perform an image-quality check of the image; perform a character-recognition process to locate a character in the image; mask the character to obtain a masked image; perform an identification process on the masked image to identify the body region of the image; perform an analysis routine on the masked image to determine a screening score, the analysis routine corresponding to the identified body region; and, if the screening score is within a normal range for the analysis routine, generate a normal notification indicating that the image is a normal image within a healthy range for the identified body region. The normal notification is automatically transmitted to a requester.

Abstract: Provided are a cell secreted-type amylospheroids-like structure, a drug and vaccine using the same, as well as a method of producing the same. In one aspect, the present disclosure relates to a production method including a step of culturing, in a culture medium, cells that express an amyloid precursor protein (APP) or a part thereof containing an amyloid beta-protein (Aß) sequence to obtain a cell secreted-type amylospheroids (ASPD)-like structure in said culture medium.

Abstract: The present invention provides compositions and methods that provide a high degree of sensitivity and a high degree of specificity for the preoperative assessment of ovarian tumors in an African American subject (e.g., pre- and post-menopausal women) having a variety of ovarian cancer types (e.g., clear cell/mucinous, low malignant potential, high malignant potential) and at a variety of disease states (e.g., early and late stage).

Abstract: The present invention is directed to a method of treating poultry hatchlings in a hatchling tray. The method comprises of providing a soft gel form capable of being dispensed through a spray nozzle, providing a spray dispensing apparatus, the apparatus being capable of delivering a predetermined volume of the gel as a plurality of small beadlets through a plurality of nozzles, placing the hatchling tray containing the hatchlings beneath the nozzles of the dispensing apparatus, dispensing the predetermined volume of the soft gel containing the therapeutic agent as small beadlets into the hatchling tray and allowing the hatchlings to consume the beadlets. The present invention is also directed to a dispensing apparatus for dispensing a therapeutic agent in a soft gel into a hatchling tray of poultry hatchlings.

Abstract: The present invention describes compositions, and associated methods, comprising a cannabinoid operably linked with a biologically active agent for augmented cannabinoid agents.

Abstract: Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy.

Abstract: An absorbent article including at least a topsheet layer and a backsheet layer, each layer having a body facing surface and a garment facing surface, and longitudinal and transversal edges, the article having a longitudinal front portion, a longitudinal back portion and a crotch portion located between the front and the back portion, the article includes a first zone of microencapsulated phase change material on a surface of a layer of the article, and wherein the first zone has a non-linear boundary in at least the transversal direction of the article.

Abstract: The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.

Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied transabdominally and directed at the cervix.

Abstract: An emergency event detection and response system detects an occurrence of an event associated with a user and initiates an emergency response flow. A user may be associated with a wearable device and have in his home a base station and portable or stationary wireless devices containing sensors capable of detecting an emergency event. The emergency event may be detected based on voice or non-voice audio input from the user, data monitoring by the wearable device, base station, and/or portable or stationary wireless device, or by physical button press. Responsive to determining that an emergency event has occurred, the system triggers an emergency response flow by notifying a call center and contacting one or more caregivers associated with the user. Caregivers may access a response system application to receive updates regarding the detected emergency and to contact the user and/or a provider associated with the call center.

Abstract: An exercise machine may include a stationary frame, an inclinable portion movably connected to the stationary frame, and an incline mechanism connected to the stationary frame. The incline mechanism may include a coiling mechanism, a coiling rod of the coiling mechanism, a flexible coiling link movable with a rotation of the coiling rod, and where the flexible coiling link is connected to the inclinable portion.