Abstract: The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1) promoter, wherein the one or more reporter proteins are expressed under the control of the MCP-1 promoter. A method for monitoring endogenous expression of MCP-1 in vivo is also provided, which is useful for identifying a regulator of the expression of MCP-1 or an anti-inflammatory agent.

Abstract: An apparatus for imaging a tooth having a light source with a first spectral range and a second spectral range. A polarizing beamsplitter (18) light having a first polarization state toward the tooth and directs light from the tooth having a second polarization state along a return path toward a sensor (68), wherein the first and second polarization states are orthogonal. A first lens (22) in the return path directs image-bearing light from the tooth, through the polarizing beamsplitter (18), toward the sensor (68), and obtains image data from the redirected portion of the light having the second polarization state. A long-pass filter (15) in the return path attenuates light in the second spectral range. Control logic enables the sensor to obtain either the reflectance image or the fluorescence image.

Abstract: A method and apparatus for metering a liquid nutritional supplement is disclosed and provides a liquid dispenser having a body that contains a predetermined number of single dosages of the liquid nutritional supplement, a cap, such as a child resistant cap, coupled to a neck portion of the body, and a dosage cup coupled to the cap. The dosage cup has at least four axial shoulders on an inside surface thereof wherein each has an engaging surface adapted to engage axial ridges of the cap. The dosage cup is coupled to the cap such that a force that is greater, by a predetermined amount, than the weight of the dosage cup is required to remove the dosage cup from the cap. The dosage cup is provided with an indicator adapted to indicate one of the single dosages of the liquid nutritional supplement to be consumed by a user for a predetermined time period.

Abstract: The present invention describes a system and method of using individuals' behavioral and physiologic information to identify disease-influencing genes.

Abstract: A re-use prevention mechanism (160) for an apparatus (110) having a reusable part (120) and a single-use disposable part (130) connectable to the reusable part (120) is disclosed. The re-use prevention mechanism (160) comprises a blocking portion (1603) disposed, in use, between the disposable part (130) and the reusable part (120). An actuating member (1605) is operable between the blocking portion (1603) and one of the disposable part (130) and the reusable part (120) for moving the blocking portion (1603) into a blocking position upon disconnection of the disposable part (130) from the reusable part (120). hi the blocking position, the blocking portion (1603) engages an abutment surface (1206) on one of the disposable part (130) and the reusable part (120) if a user attempts to reconnect the disposable part (130) to the reusable part (120) and thereby prevents re-connection of the disposable part (130) to the reusable part (120).

Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

Abstract: The present invention is concerned with cancer treatment and diagnosis, especially with melanoma associated peptide analogues with improved immunogenicity, epitopes thereof; vaccines against melanoma, tumor infiltrating T lymphocytes recognizing the antigen and diagnostics for the detection of melanoma and for the monitoring of vaccination. The peptides according to the invention can be exploited to elicit native epitope-reactive Cm. Usage of the peptides with improved immunogenicity may contribute to the development of CTL-epitope based vaccines in viral disease and cancer.

Abstract: A method for identifying the orientation of a radiographic image of a patient generates a reduced-scale image having a smaller number of pixel elements than the original radiographic image and generates a reduced bit-depth image from the reduced-scale image. The method determines whether the image has portrait or landscape orientation by sectioning either the reduced-scale image or the reduced bit-depth image into at least two sections and calculating at least one value related to relative symmetry for each of the at least two sections.

Abstract: An apparatus for obtaining images of a tooth comprises at least one image sensor disposed along an optical axis to take polarized reflectance image and fluorescence image, at least one broadband illumination apparatus for reflectance imaging, and a narrow-band ultraviolet illumination apparatus for fluorescence imaging. In order to remove the specular reflection, one or more polarization elements are disposed along the optical axis. A filter is disposed along the optical axis to block narrow-band ultraviolet light, and a switch for selecting one of the operation modes.

Abstract: A method for forming an electronic circuit disposes a plurality of magnets onto a flux plate to form a magnetic platen. A substrate package is formed using the magnetic platen and, stacked against the magnetic platen, a non-magnetic carrier and a substrate layer, with a bonding material sandwiched between the carrier and the substrate layer, and with the carrier layer disposed nearest the magnetic platen. A fused wafer stack is formed by heating the substrate package to adhere the substrate layer to the carrier. The fused wafer stack is removed from the magnetic platen and the circuit fabricated on the substrate layer.

Abstract: Methods for generating highly enriched Th1/Tc1 and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.

Abstract: Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.

Abstract: A bubbling bath additive 42 made of a surfactant 46 and a bubbling agent 44, and a housing member 12 for housing the bubbling bath additive 42 are provided. A floating part 22, 34 that is situated above the housing member 12 and floats on the water surface, and an ejection port 33 that is provided above the waterline of the floating part 22, 34 and through which bubbles formed by the bubbling bath additive 42 are ejected outward from inside, are provided. A suction port 14 through which water flows inward from outside is provided near a lower end part of the housing member 12.

Abstract: The invention relates to an electrochemical sensor and method for providing the sensor having an insulator, an electrode deposited on the insulator, an electrolytic material in contact with the electrode for providing an electrical connection, and a cooling and heating element in contact with the insulator and spaced apart from the electrode for adjusting a temperature of the sensor.

Abstract: A continuous positive airway pressure (“CPAP”) mask is provided. The CPAP mask includes a mask support that includes a cavity provided within the mask support. The CPAP mask further includes a mask cushion that is received within the cavity. The mask cushion and the mask support each include an opening. Air can pass from an air delivery tube through the openings and into the mask cushion. The mask cushion can be placed around a patient's breathing orifice to deliver the air to the patient. The CPAP mask further includes a forehead support that is spaced apart form the mask support. A neck portion attaches the forehead support to the mask support. The neck portion is flexible and is molded to both the mask support and the forehead support. The flexible neck portion allows the mask support to move with respect to the forehead support.

Abstract: The invention relates to nonaqueous pharmaceutical preparations comprising a glucocorticoid ester and an acid, and to the stabilization of glucocorticoid esters in such preparations by acids.

Abstract: The present invention relates a use of the electrocapture-based separation technology combined with mass spectrometrical fragmentation methods, e.g. sequence of polypeptides by collision-induce dissociation mass spectrometry, for the identification and/or characterization molecules of interest. It also relates the combination of the electrocapture-base separation technology with other liquid separation methods, as e.g. liquid chromatography, in order to achieve multi-dimensional separations prior mass spectrometrical analysis. In addition, it relates physical interfaces between electrocapture-based separations and different types mass spectrometers for on-line or off-line analysis, as well as the coupling of electrocapture-based separations, liquid chromatography and different types of mass spectrometrometers.

Abstract: The present invention relates to a pesticidal control device that includes at least one pesticidal active ingredient, cellulose fibers, and a polymer or polymer matrix. he combination of the cellulose fibers with the polymer allows for a higher loading of liquid pesticidal active ingredients within the pesticidal control device, maintains the active ingredient within the control device during transportation, storage and handling, and provides higher efficacy or control of pests during treatment. The pesticidal control device may be an ear tag, collar, or bee strip.

Abstract: Disclosed are methods of isolating and using a population of FOXP3+ regulatory T cells in a variety of preventative and therapeutic approaches to autoimmune diseases, graft-versus-host disease and transplant rejection.

Abstract: The present invention in one aspect relates generally to the identification, provision and use of a plurality of biomarkers to provide risk assessment of a subject having glioblastoma multiforme, and products and processes related thereto. In one aspect, a novel plurality of biomarkers as described herein is provided to determine a risk of glioblastoma multiforme. In another aspect, a novel plurality of biomarkers as described herein is provided to diagnose a subject having glioblastoma multiforme. In yet another aspect are methods for treating a subject having glioblastoma multiforme by administering one or more therapeutic regimens for glioblastoma multiforme. In yet another aspect are nucleic acid arrays comprising nucleic acid probes that hybridize to one or more glioblastoma multiforme genes.