Abstract: A prosthesis system for minimally invasive femoral head replacement surgery includes a prosthesis having a first and second ends, a femoral head prosthesis being provided at the first end of the prosthesis, the prosthesis being provided with a nail hole, and the femoral head prosthesis partially protruding from the first end of the channel; an extension rod detachably and fixedly connected with the second end of the prosthesis; a guiding frame having a positioning sleeve and a guiding sleeve, the positioning sleeve being sleeved outside the extension rod and positioning the extension rod, after the extension rod is positioned, a center line of the guiding sleeve and a center line of the nail hole are on the same straight line; and a locking nail fixed to the nail hole of the prosthesis, both ends of the locking nail protruding out of the prosthesis.