Abstract: A method for computer-aided sheet running control in a sheet-fed printing machine includes, during a printing operation, using a measuring sensor to detect a printed sheet in the printing machine and using an activation sensor to initiate measuring performed by the measuring sensor by emitting an activation signal. The activation sensor is mechanically fixedly installed without adjustment, and temporal deviations of the activation signal are determined and compensated. A system for computer-aided sheet running control in a sheet-fed printing machine is also provided.