Patents Assigned to Heinrich Mack Nachf. Chem.-Pharmazeutische Fabrik
  • Process for the preparation of isosorbide 2-nitrate
    Patent number: 4417065
    Abstract: A process for the preparation of isosorbide-2-nitrate of the formula ##STR1## comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: November 22, 1983
    Assignee: Heinrich Mack Nachf. Chem.-Pharmazeutische Fabrik
    Inventor: Peter Stoss