Abstract: A computer system, including a computing module, a communication module, and at least one I/O interface is described. The computing module includes a COM Express module and/or a COM HPC module. The communication module includes a SMARC module and/or a Qseven module. The communication module has an FPGA module which is connected in a signal-transmitting manner to the computing module and to the at least one I/O interface. The FPGA module is configured to communicate with the computing module based on at least one first communication standard, and to communicate with the at least one I/O interface based on at least one second communication standard. The FPGA module is configured to convert signals from the least one first communication standard to the at least one second communication standard and vice versa. The computing module is configured as a host, and the communication module is configured as a client. A method of operating a computer system is furthermore described.