Patents Assigned to Heldelberg Pharma GmbH
  • Amatoxin-conjugates with improved linkers
    Patent number: 9399681
    Abstract: The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by a linker comprising a urea moiety, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: July 26, 2016
    Assignee: Heldelberg Pharma GmbH
    Inventors: Jan Anderl, Werner Simon, Christoph Mueller