Patents Assigned to Helix BioPharma Corporation
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Patent number: 11931422Abstract: Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.Type: GrantFiled: January 22, 2016Date of Patent: March 19, 2024Assignee: HELIX BIOPHARMA CORPORATIONInventors: Heman Chao, Wah Yau Wong, Baomin Tian, Kimberly Jayne Gaspar, Praveen Kumar
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Publication number: 20180000963Abstract: Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.Type: ApplicationFiled: January 22, 2016Publication date: January 4, 2018Applicant: HELIX BIOPHARMA CORPORATIONInventors: Heman CHAO, Wah Yau WONG, Baomin TIAN, Kimberly Jayne GASPAR, Praveen KUMAR
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Patent number: 9011924Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: GrantFiled: October 21, 2013Date of Patent: April 21, 2015Assignee: Helix Biopharma CorporationInventor: Praveen Kumar
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Patent number: 8992969Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: GrantFiled: October 21, 2013Date of Patent: March 31, 2015Assignee: Helix BioPharma CorporationInventor: Praveen Kumar
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Patent number: 8986732Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: GrantFiled: August 12, 2013Date of Patent: March 24, 2015Assignee: Helix BioPharma CorporationInventor: Praveen Kumar
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Publication number: 20150044276Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: ApplicationFiled: October 21, 2013Publication date: February 12, 2015Applicant: Helix BioPharma CorporationInventor: Praveen Kumar
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Publication number: 20150044274Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: ApplicationFiled: August 12, 2013Publication date: February 12, 2015Applicant: Helix BioPharma CorporationInventor: Praveen Kumar
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Publication number: 20150044292Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: ApplicationFiled: October 21, 2013Publication date: February 12, 2015Applicant: Helix BioPharma CorporationInventor: Praveen Kumar
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Publication number: 20150044275Abstract: This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery.Type: ApplicationFiled: August 12, 2013Publication date: February 12, 2015Applicant: Helix BioPharma CorporationInventor: Praveen Kumar
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Patent number: 8945529Abstract: A biphasic lipid vesicle composition for treating cervical displasia by intravaginal delivery. The composition includes a suspension of lipid-bilayer vesicles having entrapped therein, an oil-in-water emulsion, human interferon alpha-2b and L-methionine, the composition having an interferon alpha-2b specific activity of between about 1-10 MIU (million international units) per gram composition, and between 0.01 to 0.5 weight percent L-methionine. In the treatment method, the composition is administered at a dose of between about 1-20 MIU interferon alpha-2b, and this dose is administered at least 3 days/week, for a period of at least 4 weeks.Type: GrantFiled: March 27, 2008Date of Patent: February 3, 2015Assignee: Helix BioPharma CorporationInventors: Marianna Foldvari, Praveen Kumar, John M. Docherty
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Patent number: 7264800Abstract: Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose extracellular environment contains 1–8 mM urea, by exposing the cells to a weakly basic anti-cancer compound which is effective in inhibiting the growth of the cells. The improvement includes (a) exposing the cells to a urease enzyme composition and, (b) by step (a), reducing the amount of anti-cancer compound required to produce a given extent of inhibition in the growth of the cells when the cells are exposed to the anti-cancer agent. Methods of potentiating the specific therapeutic activity of a weakly basic anti-cancer compound in the treatment of a given mammalian cancer which is responsive to the compound are provided as are pharmaceutical compositions for use in intravenous administration to a subject are also provided.Type: GrantFiled: January 27, 2005Date of Patent: September 4, 2007Assignee: Helix BioPharma CorporationInventors: Donald Segal, Jerry McElroy, Heman Chao, Wah Y. Wong, John Docherty, Jodi Dickstein
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Patent number: 7211250Abstract: A pharmaceutical composition and method for use in inhibiting growth of cancer cells in a mammalian subject are disclosed. The composition includes a urease enzyme, and associated therewith, a chemical entity effective to enhance the delivery of the enzyme to cancer cells, when the composition is administered to the subject. Also disclosed are a method of enhancing the effectiveness of weakly basic anti-tumor compounds, a method assessing the presence, size or condition a solid tumor in a subject, and a gene therapy composition for treating a cancer in a subject.Type: GrantFiled: July 16, 2003Date of Patent: May 1, 2007Assignee: Helix Biopharma CorporationInventors: Don Segal, Jerry McElroy, Heman Chao, Wah Wong, John Docherty, Jodi Dickstein
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Patent number: 6787368Abstract: A diagnostic method and device for use in detecting or quantitating an analyte present in a liquid sample. The method includes reacting an analyte-containing sample with reagents capable of generating a first coil-forming peptide in solution form. This peptide is then contacted with a biosensor whose detection surface has surface-bound molecules of a second, oppositely charged coil-forming peptide, under conditions effective to form a stable &agr;-helical coiled-coil heterodimer on the detection surface. The formation of the coiled-coil heterodimer produces a measurable change in biosensor signal, which is measured to detect the presence of or quantitate the amount of analyte in a sample. Also disclosed is a biosensor device for carrying out the reaction.Type: GrantFiled: March 2, 2000Date of Patent: September 7, 2004Assignee: Helix BioPharma CorporationInventors: Wah Y. Wong, Heman Chao, Donald Segal, Jerry McElroy
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Patent number: 6300141Abstract: A diagnostic card device for use in detecting or quantitating an analyte present in a liquid sample, comprising a card substrate having a sample introduction region, a biosensor, and a sample-flow pathway communicating between the sample-introduction region and the biosensor, circuitry for generating an analyte-dependent electrical signal from the biosensor; and a signal-responsive element for recording such signal. In one embodiment, the biosensor includes a detection surface with surface-bound molecules of a first charged, coil-forming peptide capable of interacting with a second, oppositely charged coil-forming peptide to form a stable &agr;-helical coiled-coil heterodimer, where the binding of the second peptide to the first peptide, to form such heterodimer, is effective to measurably alter a signal generated by the biosensor. The sample-flow pathway contains diffusibly bound conjugate of the second coil-forming peptide and the analyte (or an analyte analog) and immobilized analyte-binding agent.Type: GrantFiled: March 2, 2000Date of Patent: October 9, 2001Assignee: Helix BioPharma CorporationInventors: Donald Segal, Heman Chao, Wah Y. Wong, Jerry McElroy