Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: In a first aspect, the present invention relates to the use of a TLR 9 agonist and/or a TLR 4 agonist in a prophylactic or therapeutic vaccine. According to the present vaccination strategy, the TLR 9 agonist and/or TLR 4 agonist is adapted or designed for use as a multiplying jump agent to enhance numbers and functionality of CD8 T cells in a prime-jump vaccination strategy for jump T cell expansion. In particular, the TLR 9 agonist and/or TLR 4 agonist is used as a component to be administered after priming of the individual to be vaccinated. The vaccination strategy is particularly useful against acute and chronic infections with intracellular pathogens or for anti-tumor vaccination. In another aspect, the present invention relates to a kit of part containing a prime agent and a multiplying jump agent according to the present invention.

Abstract: An imaging apparatus (100), configured for thermoacoustic tomographic imaging a region of interest (2) in an object (1), comprises a source device (10) being arranged for emitting an electromagnetic energy input into the region of interest (2), a detector device (20) being arranged for detecting mechanical wave response signals generated in the region of interest (2) along multiple angular projection directions in response to the electromagnetic energy input, and an image data acquisition and processing device (30) being arranged for providing tomographic image data representing the image of the region of interest (2) on the basis of the mechanical wave response signals, wherein the source device (10) is adapted for continuously emitting the electromagnetic energy input with a predetermined input modulation, and the image data acquisition and processing device (30) is adapted for converting the mechanical wave response signals into the frequency domain and for performing data processing and image reconstructi

Abstract: A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite.

Abstract: The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric m

Abstract: The present invention relates to a method of diagnosing endometriosis, the method comprising (i) determining in a sample obtained from a subject: (a) the concentration of SMOH C16:1 and the ratio of the concentration of PCaa C36:2 to the concentration of PCae C34:2; (b) the concentration of PCae C30.0, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (c) the concentration of PCae C36.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (d) the concentration of SM C16.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.2 and the ratio of the concentration of Trp to the concentration of PCae C34.0; (e) the concentration of SM C16.1, the ratio of the concentration of PCaa C36.2 to the concentration of PCae C36.

Abstract: An autostereoscopic display includes a background illumination with a multiplicity of parallel light strip groups with in each case at least two parallel light strips, wherein the individual light strip groups are arranged next to one another with a first grid dimension, and a lens grid arranged before the background illumination and has a multiplicity of parallel lens strips, wherein the lens strips are arranged next to one another with a second grid dimension, as well as a light modulator arranged before the lens grid and displays image information.

Abstract: The present invention discloses an ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens for use in the prophylaxis and treatment of patients with a reduced T cell activity in order to prevent or treat growth of EBV infected B cells.

Abstract: A tomography apparatus that generates images of an object includes a radiation source emitting a radiation beam, wherein the radiation beam rotates around the object and penetrates the object; a radiation detector rotating around the object opposite the radiation source so that the radiation detector detects the radiation beam after penetration of the object; a radiation mask surrounding the object that masks the radiation beam, wherein the radiation mask is arranged in a path of the radiation beam between the radiation source and the radiation detector and the radiation beam passes the radiation mask only once between the radiation source and the radiation detector.

Abstract: The present invention relates to a plant protective composition comprising ?-hydroxy-acid or a derivative thereof. The present invention further relates to a method of protecting plants from biotrophic pathogens comprising contacting the plants with the plant protective composition.

Abstract: The present invention relates to a method for the degradation of pollutants in water and/or soil. More specific, the present invention relates to a method for the on-site decontamination or re-mediation of water and/or soil which are contaminated with organic compounds. Moreover, the invention relates to a method for forming a barrier against the spreading of a contamination with pollutants within the water and/or soil, especially within groundwater (aquifer). Further, the invention relates to means for use in these methods, and to the production of such means.

Abstract: The invention relates to a method for in vitro maturation of at least one immate dendritic cell, comprising stimulating said immature dendritic cell with TNF?, IL-1?, IFN?, a TLR7/8 agonist and prostaglandin E2(PG). Furthermore, the invention elates to a composition comprising these factors as well as to mature dendritic cells produced by a method of the invention.

Abstract: The invention relates to a compound for use in treating a cancer, wherein the cancer depends on the proteolytic activity of the MALT1 protease, and wherein the compound has the general formula (I) wherein X is N or C; Y is S, O, SO2, SO, NH, CO, CH2, CH?CH, CH2?CH2; ( )z is a C1-C5 linear or branched alkyl chain; A is NR3R4, or OR5, or HET; R1 and R2 in each occurrence are independently selected from —H, —CH3, —OH, —OCH3, —SCH3, —F, —Cl, —CF3, —NH2, and —COOH; R3, R4, and R5 are H, or C1-C5 linear or branched alkyl groups, and HET is a heterocyclic ring of 5, 6, or 7 members, wherein the ring atoms can be C, O, N, or S, the ring can be saturated or aromatic, and the ring can be substituted with H or C1-C5 linear or branched alkyl groups; or a pharmaceutically acceptable salt, prodrug, enantiomer, diastereomer, racemic mixture, crystalline form, amorphous form, unsolvated form or solvate of said compound. The compound of the invention may further be used in the treatment of MALT1-dependent immune diseases.

Abstract: The present invention relates to a nucleic acid molecule encoding a polypeptide having a fluorescence emission activity with a maximum emission at 505 to 515 nm, wherein said nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO: 1; (c) a nucleic acid molecule hybridizing under stringent conditions to the complementary strand of (i.

Abstract: An ultrasound detector adapted for ultrasound detection with medical applications includes an optical waveguide, and at least one Bragg grating, created with a predetermined refractive index modulation amplitude in the optical waveguide, wherein the at least one Bragg grating includes a localized defect in periodicity so that a localized-light resonance portion is formed around the defect, and the localized-light resonance portion has spectral properties capable of being modulated in response to an ultrasound oscillation, wherein the optical waveguide is a non-amplifying optical medium, and the refractive index modulation amplitude is selected such that the localized-light resonance portion is concentrated at the defect in periodicity and the ultrasound oscillation can be sensed by the at least one Bragg grating with an acoustic sensitivity most of which being obtained over the localized-light resonance portion.

Abstract: The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.

Abstract: A scanner device for computed tomography imaging of an object, includes a measurement device including a source device arranged for irradiating the object with at least one beam and a detector device arranged for detecting radiation transmitted through the object, wherein the source device has a fixed position relative the detector device, and a carrier device accommodating the object in a position between the source device and the detector device, wherein the measurement device and the carrier device are capable of a scanning movement relative to each other, and the measurement device and the carrier device have a fixed spatial orientation during the scanning movement. Furthermore, a scanning method for computed tomography imaging of an object is described.

Abstract: The invention relates to a radiation detector (10), in particular for detecting x-ray radiation, comprising a carrier substrate (11), a detector layer (12) which comprises GaN, is arranged on the carrier substrate (11) and has a thickness less than 50 ?m, and contact electrodes (13) which form ohmic contacts with the detector layer (12). The invention also relates to a measurement device which is equipped with at least one such radiation detector (10).

Abstract: The invention relates to a method for in vitro maturation of at least one immature dendritic cell, comprising stimulating said immature dendritic cell with TNF?, IL- 1?, IFN?, a TLR7/8 agonist and prostaglandin E2 (PG). Furthermore, the invention relates to a composition comprising these factors as well as to mature dendritic cells produced by a method of the invention.

Abstract: An artificial airway including an airway tube having proximal and distal ends and a mask mounted at the distal end of the airway tube characterized in that the airway tube includes a curved portion adjacent to its distal end and a straight portion extending from the curved portion to the proximal end of the airway tube and the curved portion is more rigid than the straight portion.