Patents Assigned to Helperby Therapeutics Limited
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Publication number: 20160331773Abstract: The present invention relates to the use of a combination of an anti-retroviral agent such as zidovudine and anti-microbial agents for killing clinically latent microorganisms associated with microbial infections and to novel combinations comprising an anti-retroviral agent such as zidovudine and anti-microbial agents for the treatment of microbial infections.Type: ApplicationFiled: January 29, 2015Publication date: November 17, 2016Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Anthony Coates, Yanmin Hu
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Publication number: 20160082073Abstract: The present invention relates to a combination comprising at least one compound selected from the group consisting of an ?-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator, a vitamin, or a pharmaceutically acceptable derivative thereof; and an antimicrobial compound.Type: ApplicationFiled: September 22, 2015Publication date: March 24, 2016Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin HU, Anthony RM COATES
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Publication number: 20160038438Abstract: The present invention relates to the use of a combination of nordihydroguaiaretic acid and an aminoglycoside for treating a microbial infection or for killing clinically latent microorganisms associated with microbial infections.Type: ApplicationFiled: May 2, 2014Publication date: February 11, 2016Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Anthony COATES, Yanmin HU
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Publication number: 20160030506Abstract: The present invention relates to the use of a combination of an anti-retroviral agent such as zidovudine and an anti-microbial agent for killing clinically latent microorganisms associated with microbial infections and to novel combinations comprising an anti-retroviral agent such as zidovudine and an anti-microbial agent for the treatment of microbial infections.Type: ApplicationFiled: March 20, 2014Publication date: February 4, 2016Applicant: Helperby Therapeutics LimitedInventors: Yanmin HU, Anthony COATES
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Patent number: 9216186Abstract: This invention relates to the use of 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline or a pharmaceutically acceptable derivative thereof in combination with an aminoglycoside antimicrobial agent for the prevention and/or treatment of microbial infections.Type: GrantFiled: August 5, 2011Date of Patent: December 22, 2015Assignee: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony R. M. Coates
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Patent number: 8940723Abstract: This invention relates to the use of 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline or a pharmaceutically acceptable derivative thereof in combination with another antimicrobial agent selected from the group consisting of a beta-lactam antimicrobial agent, mupirocin and chlorhexidine or a pharmaceutically acceptable derivative thereof, for the prevention and/or treatment of microbial infections.Type: GrantFiled: August 5, 2011Date of Patent: January 27, 2015Assignee: Helperby Therapeutics LimitedInventors: Yanmin Hu, Anthony R. M. Coates
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Patent number: 8759348Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.Type: GrantFiled: May 16, 2008Date of Patent: June 24, 2014Assignee: Helperby Therapeutics LimitedInventors: Mandy Christine Beswick, Susan Mary Cramp, Yanmin Hu, Thomas David Pallin, Hazel Joan Dyke, Anthony Coates
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Publication number: 20130243886Abstract: The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.Type: ApplicationFiled: September 9, 2011Publication date: September 19, 2013Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony RM Coates
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Publication number: 20130245060Abstract: This invention relates to topical pharmaceutical compositions comprising the active agent 4-methyl-1-(2-phenylethyl)-8-phenoxy-2,3-dihydro-1H-pyrrolo[3,2-c]-quinoline or a pharmaceutically acceptable derivative thereof and a hydrophobic excipient, to a process for preparing such compositions, and to the use of such compositions for the treatment of microbial infections.Type: ApplicationFiled: October 7, 2011Publication date: September 19, 2013Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony Rm Coates
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Publication number: 20130184230Abstract: This invention relates to the use of 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline or a pharmaceutically acceptable derivative thereof in combination with another antimicrobial agent selected from the group consisting of a beta-lactam antimicrobial agent, mupirocin and chlorhexidine or a pharmaceutically acceptable derivative thereof, for the prevention and/or treatment of microbial infections.Type: ApplicationFiled: August 5, 2011Publication date: July 18, 2013Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony R.M. Coates
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Publication number: 20130137652Abstract: This invention relates to the use of 4-methyl-8-phenoxy-1-(2-phenylethyl)-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline or a pharmaceutically acceptable derivative thereof in combination with an aminoglycoside antimicrobial agent for the prevention and/or treatment of microbial infections.Type: ApplicationFiled: August 5, 2011Publication date: May 30, 2013Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony R.M. Coates
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Publication number: 20130096151Abstract: The present invention relates to the use of an anesthetic agent for killing clinically latent microorganisms associated with microbial infections and to novel combinations comprising an anesthetic agent and an antimicrobial agent for the treatment of microbial infections.Type: ApplicationFiled: March 29, 2011Publication date: April 18, 2013Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Yanmin Hu, Anthony M.R. Coates
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Publication number: 20120231995Abstract: There is provided the use of compounds of formula I wherein R1, R2, R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.Type: ApplicationFiled: May 17, 2012Publication date: September 13, 2012Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Petra Helga Beck, Marc Barry Brown, David Edward Clark, Anthony Coates, Hazel Joan Dyke, Yanmin Hu, Derek John Londesbrough, Keith Mills, Thomas David Pallin, Gary Patrick Reid, Gerlinda Stoddart
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Patent number: 8207187Abstract: There is provided the use of compounds of formula I wherein R1, R2, R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.Type: GrantFiled: November 8, 2006Date of Patent: June 26, 2012Assignee: Helperby Therapeutics LimitedInventors: Petra Helga Beck, Marc Barry Brown, David Edward Clark, Anthony Coates, Hazel Joan Dyke, Yanmin Hu, Derek John Londesbrough, Keith Mills, Thomas David Pallin, Gary Patrick Reid, Gerlinda Stoddart
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Publication number: 20110052616Abstract: The present invention concerns a peptide molecule or a nucleic acid molecule, for use in medicine and, in particular, for use in preventing or treating a non-cancerous condition or relieving pain in a patient. The invention also relates to a pharmaceutical composition comprising the peptide or nucleic acid molecule of the invention and methods of treatment thereof.Type: ApplicationFiled: February 25, 2009Publication date: March 3, 2011Applicant: Helperby Therapeutics LimitedInventors: Anthony Robert Milnes Coates, Yanira Riffo-Vasquez, Peter Tormay
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Patent number: 7892782Abstract: The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of antibacterial agents, the subpopulation thus identified, a process for identifying new antibacterial agents by testing against the antibiotic-resistant subpopulation, the compounds thus identified and their uses, particularly in treating bacterial infections involving dormant bacteria.Type: GrantFiled: December 23, 2008Date of Patent: February 22, 2011Assignee: Helperby Therapeutics LimitedInventors: Anthony Robert Milnes Coates, Yanmin Hu
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Publication number: 20100305065Abstract: There is provided the use of compounds of formula wherein R1, R2, R3 and E have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula (I) per se.Type: ApplicationFiled: May 16, 2008Publication date: December 2, 2010Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Mandy Christine Beswick, Susan Mary Cramp, Yanmin Hu, Thomas David Pallin, Hazel Joan Dyke, Anthony Coates
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Patent number: 7744906Abstract: The present invention concerns the use of a heat shock polypeptide and/or an encoding nucleic acid sequence in the manufacture of a medicament for use in the relief of pain. In particular the invention concerns the use of chaperonin. The invention further provides methods of relieving pain medicaments containing the heat shock polypeptides.Type: GrantFiled: November 5, 2003Date of Patent: June 29, 2010Assignee: Helperby Therapeutics LimitedInventor: Anthony Robert Milnes Coates
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Publication number: 20100093691Abstract: There is provided topical pharmaceutical compositions comprising compounds of formula I wherein R1, R2, R3 and X have meanings given in the description. These compositions can be used to treat microbial infections and to kill clinically latent microorganisms.Type: ApplicationFiled: November 8, 2007Publication date: April 15, 2010Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Petra Helga BECK, Marc Barry Brown, Anthony Coates, Yanmin Hu, Gerlinda Stoddart
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Publication number: 20090137622Abstract: There is provided the use of compounds of formula I wherein R1, R2, R3 and X have meanings given in the description, for the preparation of a medicament for killing clinically latent microorganisms. There is also provided the use of compounds of formula I for treating microbial infections, as well as certain compounds of formula I per se.Type: ApplicationFiled: November 8, 2006Publication date: May 28, 2009Applicant: HELPERBY THERAPEUTICS LIMITEDInventors: Petra Helga Beck, Marc Barry Brown, David Edward Clark, Anthony Coates, Hazel Joan Dyke, Yanmin Hu, Derek John Londesbrough, Keith Mills, Thomas David Pallin, Gary Patrick Reid, Gerlinda Stoddart