Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Type:
Grant
Filed:
March 1, 1996
Date of Patent:
November 24, 1998
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
Inventors:
Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
Abstract: Provided are materials and methods for predicting whether a molar tooth will remain impacted or will erupt based upon anatomical measurements of the position of the teeth in relation to the ascending ramus of the mandible.
Type:
Grant
Filed:
January 12, 1995
Date of Patent:
October 6, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Irja Venta, Heikki Murtomaa, Pekka Ylipaavalniemi
Abstract: Disclosed are improvements for enzyme-catalyzed reactions involving DNA or RNA, including PCR, which are based on conducting such reactions in the presence of lipids.
Type:
Grant
Filed:
June 20, 1995
Date of Patent:
August 11, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Paavo Kai Johannes Kinnunen, Pekka Kristian Mustonen, Juha Kalervo Kere
Abstract: FLT4 gene, expression systems and proteins are provided for use in diagnosis and treatment of conditions related to the tyrosine kinase receptor encoded by the FLT4 gene.
Type:
Grant
Filed:
November 14, 1994
Date of Patent:
July 7, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Kari Alitalo, Olga Aprelikova, Katri Pajusola, Elina Armstrong, Jaana Korhonen, Arja Kaipainen
Abstract: The present application discloses a novel method for the detection of Staphylococcus aureus and methicillin-resistant strains of Staphylococcus aureus. Further disclosed is an approximately 230 kDa protein and the use of such protein in detection assays for Staphylococcus aureus and in other diagnostic and therapeutic applications. Also disclosed are methods of purifying the protein and biologically active fragments thereof.
Abstract: Materials and methods are presented for the isolation of lipids from a mixture of lipids using a supercritical fluid extraction process. Lipids are isolated by methods according to the invention in an amount approximately equal to the amount of the specified material in the mixture prior to extraction.
Type:
Grant
Filed:
November 25, 1994
Date of Patent:
June 2, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Raimo Vilho Kari Hiltunen, Heikki Juhani Vuorela
Abstract: The working quality of the human brain is measured with this method and apparatus by determining the highest frequency at which a subject can discriminate between synchronous and asynchronous pairs of two simultaneously presented periodic non-verbal stimuli: the higher this frequency (synchronism threshold) is the faster the brain of the subject can process information using the sensory function tested. The periodic stimuli provided to the subject and preceded by appropriate mask stimuli may be pairs of visual, tactile, electrocutaneous, and/or auditory stimuli within the same sense modality, or intermodal between two different senses. The apparatus generates the stimuli and indicates the nominal frequencies of the stimuli and threshold. The frequency threshold is determined by means of an adaptive staircase procedure in which the frequency is decreased after wrong responses and increased after correct responses.
Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
March 4, 1997
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
Inventors:
Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
Abstract: Provided are transgenic plants with resistance to viral infection, methods for conferring such resistance, and methods for producing the transgenic plants.
Type:
Grant
Filed:
May 19, 1994
Date of Patent:
November 19, 1996
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Eija Pehu, Tuula Pehu, Tuula Maki-Valkama, Jari Valkonen, Kimmo Koivu, Kirsi Lehto
Abstract: The present application discloses a novel method for the detection of Staphylococcus aureus and methicillin-resistant strains of Staphylococcus aureus. Further disclosed is an approximately 230 kDa protein and the use of such protein in detection assays for Staphylococcus aureus and in other diagnostic applications.
Abstract: Provided are materials and methods for increasing the working life of a lubricant oil in an engine, including alkaline compositions which are added to said oil, and an apparatus containing the alkaline compositions to be placed in said engine through which oil passes.