Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Type:
Grant
Filed:
May 6, 1997
Date of Patent:
December 18, 2001
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
Inventors:
Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligands, pharmaceutical compositions and diagnostic reagents.
Type:
Grant
Filed:
January 12, 1996
Date of Patent:
June 12, 2001
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing, Ltd. OY
Abstract: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
Type:
Grant
Filed:
August 21, 1997
Date of Patent:
May 22, 2001
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd.
Inventors:
Marc G. Achen, Andrew F. Wilks, Steven A. Stacker, Kari Alitalo
Abstract: Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligand, pharmaceutical compositions and diagnostic reagents.
Type:
Grant
Filed:
August 1, 1995
Date of Patent:
April 24, 2001
Assignees:
Helsinki University Licensing Ltd. Oy, Ludwig Institute for Cancer Research
Abstract: Provided are purified and isolated VEGF-C cysteine deletion variants that bind to Flt4 receptor tyrosine kinase (VEGFR-3) but demonstrate reduced binding (relative to VEGF-C) to kdr receptor tyrosine kinase (VEGFR-2); polynucleotides encoding the polypeptide; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the foregoing.
Abstract: Provided are transgenic plants with resistance to viral infection polynucleotides and methods for conferring such resistance, and methods for producing the transgenic plants. Plants transformed with a nucleotide sequence encoding a P1 protein of potato virus Y result in plants having increased resistance to infection by potato virus Y.
Type:
Grant
Filed:
November 18, 1996
Date of Patent:
October 19, 1999
Assignee:
Helsinki University Licensing Ltd. Oy
Inventors:
Eija Pehu, Tuula Pehu, Tuula Maki-Valkama, Jari Valkonen, Kimmo Koivu, Kirsi Lehto
Abstract: The present application discloses promoter sequences for Tie, an endothelial cell receptor tyrosine kinase and their use in therapy and diagnosis as well as production of proteins in blood and tissues.
Abstract: Methods are provided for diagnosing ovarian dysgenesis, comprising analysis of DNA from a patient which encodes a portion of the receptor for follicle-stimulating hormone.
Type:
Grant
Filed:
September 20, 1995
Date of Patent:
December 22, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Albert de la Chapelle, Ilpo Huhtaniemi, Kristiina Aittomaki
Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Type:
Grant
Filed:
March 1, 1996
Date of Patent:
November 24, 1998
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
Inventors:
Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
Abstract: Provided are materials and methods for predicting whether a molar tooth will remain impacted or will erupt based upon anatomical measurements of the position of the teeth in relation to the ascending ramus of the mandible.
Type:
Grant
Filed:
January 12, 1995
Date of Patent:
October 6, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Irja Venta, Heikki Murtomaa, Pekka Ylipaavalniemi
Abstract: Disclosed are improvements for enzyme-catalyzed reactions involving DNA or RNA, including PCR, which are based on conducting such reactions in the presence of lipids.
Type:
Grant
Filed:
June 20, 1995
Date of Patent:
August 11, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Paavo Kai Johannes Kinnunen, Pekka Kristian Mustonen, Juha Kalervo Kere
Abstract: The present application discloses a novel method for the detection of Staphylococcus aureus and methicillin-resistant strains of Staphylococcus aureus. Further disclosed is an approximately 230 kDa protein and the use of such protein in detection assays for Staphylococcus aureus and in other diagnostic and therapeutic applications. Also disclosed are methods of purifying the protein and biologically active fragments thereof.
Abstract: FLT4 gene, expression systems and proteins are provided for use in diagnosis and treatment of conditions related to the tyrosine kinase receptor encoded by the FLT4 gene.
Type:
Grant
Filed:
November 14, 1994
Date of Patent:
July 7, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Kari Alitalo, Olga Aprelikova, Katri Pajusola, Elina Armstrong, Jaana Korhonen, Arja Kaipainen
Abstract: Materials and methods are presented for the isolation of lipids from a mixture of lipids using a supercritical fluid extraction process. Lipids are isolated by methods according to the invention in an amount approximately equal to the amount of the specified material in the mixture prior to extraction.
Type:
Grant
Filed:
November 25, 1994
Date of Patent:
June 2, 1998
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Raimo Vilho Kari Hiltunen, Heikki Juhani Vuorela
Abstract: The working quality of the human brain is measured with this method and apparatus by determining the highest frequency at which a subject can discriminate between synchronous and asynchronous pairs of two simultaneously presented periodic non-verbal stimuli: the higher this frequency (synchronism threshold) is the faster the brain of the subject can process information using the sensory function tested. The periodic stimuli provided to the subject and preceded by appropriate mask stimuli may be pairs of visual, tactile, electrocutaneous, and/or auditory stimuli within the same sense modality, or intermodal between two different senses. The apparatus generates the stimuli and indicates the nominal frequencies of the stimuli and threshold. The frequency threshold is determined by means of an adaptive staircase procedure in which the frequency is decreased after wrong responses and increased after correct responses.
Abstract: VEGF-B polypeptides from the PDGF family of growth factors having the property of promoting mitosis and proliferation of vascular endothelial cells, DNA sequences encoding these polypeptides, pharmaceutical compositions containing them and antibodies which react with them. The VEGF-B polypeptides are useful in stimulating angiogenesis as well as in diagnostic applications.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
March 4, 1997
Assignees:
Ludwig Institute for Cancer Research, Helsinki University Licensing Ltd. Oy
Inventors:
Ulf Eriksson, Birgitta Olofsson, Kari Alitalo, Katri Pajusola
Abstract: Provided are transgenic plants with resistance to viral infection, methods for conferring such resistance, and methods for producing the transgenic plants.
Type:
Grant
Filed:
May 19, 1994
Date of Patent:
November 19, 1996
Assignee:
Helsinki University Licensing, Ltd.
Inventors:
Eija Pehu, Tuula Pehu, Tuula Maki-Valkama, Jari Valkonen, Kimmo Koivu, Kirsi Lehto
Abstract: The present application discloses a novel method for the detection of Staphylococcus aureus and methicillin-resistant strains of Staphylococcus aureus. Further disclosed is an approximately 230 kDa protein and the use of such protein in detection assays for Staphylococcus aureus and in other diagnostic applications.