Abstract: The present invention relates to isolated haemoglobin from worms belonging to the Nereididae family and its use in cell culture medium, in preservation solutions and as artificial oxygen carrier for transfusion.
Type:
Grant
Filed:
May 7, 2010
Date of Patent:
January 18, 2022
Assignee:
HEMARINA
Inventors:
Morgane Rousselot, Delphine Dutheil, Franck Zal
Abstract: The invention relates to a lyophilisate or to a powder including i) at least one globin, a globin protomer or an extracellular hemoglobin from annelids, and ii) at least one biological material from annelids that is different from said globin, from said protomer and from said hemoglobin.
Abstract: The present invention relates to devices and bioreactors capable of delivering oxygen to a cell culture using oxygen-carrying molecules. The bioreactor comprises at least two chambers separated by an oxygen-permeable membrane. The oxygen-carrying molecules are chosen from extracellular hemoglobin isolated from worm belonging to Arenicoliolae family or Nereidiolae family.
Abstract: Disclosed is a method for preserving an organ in a donation after brain death donor or a donation after cardiac death donor comprising administering to the donor a composition comprising at least one globin, one globin protomer or one extracellular hemoglobin of Annelida, a stabilizing solution and/or a solution for conserving organs, said composition having a temperature of between 0° C. and 37° C. Also disclosed is a method for conserving an organ in situ in a donation after brain death donor or a donation after cardiac death donor using normothermic ECMO or double-balloon triple-lumen catheter techniques or any other similar technique.
Type:
Grant
Filed:
May 30, 2012
Date of Patent:
January 9, 2018
Assignee:
HEMARINA
Inventors:
Delphine Dutheil, Morgane Rousselot, Thierry Hauet, Franck Zal
Abstract: A method for maintaining stem cells in the undifferentiated state by mixing the stem cells with at least one extracellular hemoglobin, globin or globin protomer from annelids.
Abstract: The invention relates to a lyophilisate or to a powder including i) at least one globin, a globin protomer or an extracellular hemoglobin from annelids, and ii) at least one biological material from annelids that is different from said globin, from said protomer and from said hemoglobin.
Abstract: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.
Type:
Grant
Filed:
July 25, 2008
Date of Patent:
September 30, 2014
Assignees:
Hemarina SA, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie (Paris 6)
Abstract: A method for maintaining stem cells in the undifferentiated state by mixing the stem cells with at least one extracellular hemoglobin, globin or globin protomer from annelids.
Abstract: The invention relates to the use of a composition comprising at least one globin, one globin protomer or one extracellular hemoglobin of Annelida, a stabilizing solution and/or a solution for conserving organs, said composition having a temperature of between 0° C. and 37° C., for preserving an organ in a donation after brain death donor or a donation after cardiac death donor. The invention also relates to a method for conserving an organ in situ in a donation after brain death donor or a donation after cardiac death donor using normothermic ECMO or double-balloon triple-lumen catheter techniques or any other similar technique.
Type:
Application
Filed:
May 30, 2012
Publication date:
April 24, 2014
Applicant:
HEMARINA
Inventors:
Delphine Dutheil, Morgane Rousselot, Thierry Hauet, Franck Zal
Abstract: The present invention relates to isolated haemoglobin from worms belonging to the Nereididae family and its use in cell culture medium, in preservation solutions and as artificial oxygen carrier for transfusion.
Type:
Application
Filed:
May 7, 2010
Publication date:
March 1, 2012
Applicant:
HEMARINA
Inventors:
Morgane Rousselot, Delphine Dutheil, Franck Zal
Abstract: The present invention relates to devices and bioreactors capable of delivering oxygen to a cell culture using oxygen-carrying molecules. The bioreactor comprises at least two chambers separated by an oxygen-permeable membrane. The oxygen-carrying molecules are chosen from extracellular hemoglobin isolated from worm belonging to Arenicoliolae family or Nereidiolae family.
Abstract: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.
Type:
Application
Filed:
July 25, 2008
Publication date:
August 19, 2010
Applicants:
HEMARINA SA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)