Patents Assigned to Hematech, LLC
  • Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
    Patent number: 7074983
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: July 11, 2006
    Assignees: Kirin Beer Kabushiki Kaisha, Hematech, LLC
    Inventors: James M. Robl, Richard A. Goldsby, Stacy E. Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara A. Osborne
  • Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
    Publication number: 20060117395
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 1, 2006
    Applicants: Hematech, LLC, Kirin Beer Kabushiki Kaisha
    Inventors: James Robl, Richard Goldsby, Stacy Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara Osborne
  • Expression of xenogenous (human) imunoglobulins in cloned, transgenic ungulates
    Publication number: 20060117394
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 1, 2006
    Applicants: Hematech, LLC, Kirin Beer Kabushiki Kaisha
    Inventors: James Robl, Richard Goldsby, Stacy Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara Osborne
  • Transgenic animals and uses thereof
    Publication number: 20060041945
    Abstract: In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.
    Type: Application
    Filed: April 21, 2005
    Publication date: February 23, 2006
    Applicants: Hematech, LLC, Kirin Beer Kabushiki Kaisha
    Inventors: James Robl, Yoshimi Kuroiwa, Poothappillai Kasinathan, Isao Ishida, Kazuma Tomizuka
  • Methods for immunoglobulin purification
    Publication number: 20050272917
    Abstract: Disclosed herein are methods for purifying immunoglobulin G (IgG). The methods feature the use of particular buffers and reagents to isolate and purify human IgG or to remove host contaminating proteins, non-human or chimeric IgG, IgG dimers, IgG aggregates, bovine serum albumin, transmissible spongiform encephalopathy, DNA, viral DNA, or viral particles from a feedstock. IgG purified by the methods described herein can be used for research, diagnostic, or therapeutic purposes.
    Type: Application
    Filed: May 13, 2005
    Publication date: December 8, 2005
    Applicants: Hematech, LLC, Kirin Beer Kabushiki Kaisha
    Inventors: Jin-An Jiao, Scott Fulton