Patents Assigned to HematoLogics, Inc.
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Patent number: 11639936Abstract: A normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the defined set of clusters. Support Vector Machine (SVM) subroutines are employed to identify reference populations of interest by generating multidimensional boundary definitions. These boundary definitions may be used to identify reference populations to use in defining or refining a centroid line or a radius or radii defining a set of normal clusters, and to characterize and compare a test set of cells to the defined set of normal clusters.Type: GrantFiled: September 19, 2017Date of Patent: May 2, 2023Assignee: Hematologics, Inc.Inventors: Michael R. Loken, Andrew P. Voigt
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Patent number: 9880155Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.Type: GrantFiled: December 5, 2013Date of Patent: January 30, 2018Assignee: Hematologics, Inc.Inventors: Michael R. Loken, Sanjaya N. Joshi
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Publication number: 20140221247Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.Type: ApplicationFiled: December 5, 2013Publication date: August 7, 2014Applicant: Hematologics, Inc.Inventors: Michael R. Loken, Sanjaya N. Joshi
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Patent number: 8630833Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.Type: GrantFiled: February 17, 2006Date of Patent: January 14, 2014Assignee: Hematologics, Inc.Inventors: Michael R. Loken, Sanjaya N. Joshi
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Publication number: 20070020670Abstract: The present invention provides improved methods for detection of minimal disease. More specifically, the invention provides methods for combining cell sorting with clonality profiling to effectively lower sensitivity limits for disease detection and to provide independent confirmation of the tumor detection without the need for patient specific assay designs.Type: ApplicationFiled: July 7, 2006Publication date: January 25, 2007Applicant: HematoLogics, Inc.Inventors: Michael Loken, Barbara Zehentner-Wilkinson
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Publication number: 20060263833Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.Type: ApplicationFiled: February 17, 2006Publication date: November 23, 2006Applicant: HematoLogics, Inc.Inventors: Michael Loken, Sanjaya Joshi
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Publication number: 20060263834Abstract: The invention provides methods for determining multi-drug resistance activity of a tumor cell that is present in a heterogeneous mixture of normal cells. The present invention relates particularly to improved quantitative methods for characterizing multi-drug resistance of selected populations of cells, including hematopoietic cell populations containing malignant cells. More specifically, the invention provides flow immunocytometric methods for determining whether malignant hematopoietic cells are resistant to a chemotherapeutic drug and for identifying agents that inhibit multi-drug resistance activity in the malignant cells.Type: ApplicationFiled: February 24, 2006Publication date: November 23, 2006Applicant: HematoLogics, Inc.Inventor: Michael Loken
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Publication number: 20060234275Abstract: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized.Type: ApplicationFiled: March 28, 2006Publication date: October 19, 2006Applicant: HematoLogics, Inc.Inventor: Michael Loken
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Patent number: 7045295Abstract: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized.Type: GrantFiled: March 30, 2005Date of Patent: May 16, 2006Assignee: HematoLogics, Inc.Inventor: Michael R Loken
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Publication number: 20050233362Abstract: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized.Type: ApplicationFiled: March 30, 2005Publication date: October 20, 2005Applicant: HematoLogics, Inc.Inventor: Michael Loken