Abstract: A novel surface treatment is provided for portions of filter media coming in contact with the filter media holder, such as a filter housing. In certain applications, the treatment is also applied to the filter media holder, depending on the application. Filter media having at least two distinct surface property modifications are provided in liquid filtration applications to enhance the performance of a filtration system, reduce the cost of the system, provide a visual means of detecting fluid bypass, and minimize fluid hold-up volume within the filter media, all with substantially no loss of performance performances parameters, even in steam sterilization applications.

Abstract: A biological fluid processing or fluid filtration system is provided having novel open and closed loop processing systems wherein the gases transferred into and out of the system during processing pass through a porous medium in upstream and/or downstream gas inlet or outlet housings or vents in a manner which precludes the fluid being processed or filtered from ever contacting the housings or vents. Each housing or vent is separated from the fluid by a column of gas in its respective transfer line. The upstream gas inlet housing or vent is in communication with the unfiltered biological fluid, and the downstream gas inlet housing or vent is in communication with the filtered biological fluid.