Abstract: Compounds, pharmaceutical compositions and methods for the therapeutic delivery of carbon monoxide to humans and other mammals that employ transition metal complexes having at least a substituted cyclopentadienyl, indenyl or fluorenyl ligand and two or more carbonyl ligands.
Type:
Grant
Filed:
January 23, 2007
Date of Patent:
March 5, 2013
Assignee:
hemoCORM Limited
Inventors:
Roberto Angelo Motterlini, Brian Ernest Mann, Tony Richard Johnson, David Alistair Scapens, Rehan Aqil, Trevor Perrior
Abstract: Metal carbonyls are used to deliver CO having biological activity, for example vasodilatation and inhibition of transplant rejection. The metal of the carbonyl is typically of groups 7 to 10, e.g. Fe and Ru. The carbonyl preferably has one or store ligands other than CO, such as amine acids, to modulate the CO release property and solubility.
Type:
Grant
Filed:
January 27, 2006
Date of Patent:
August 7, 2012
Assignee:
hemoCORM Limited
Inventors:
Roberto Angelo Motterlini, Brian Ernest Mann
Abstract: Metal carbonyls are used to deliver CO to organs to limit post-ischaemic damage. The organ may be extracorporeal, e.g. for use in a transplant, or may be an isolated organ inside or attached to the body but isolated from the blood flow. The carbonyl preferably has one or more other ligands other than CO, such as amino acids, to modulate the CO release property and solubility.
Type:
Grant
Filed:
November 20, 2003
Date of Patent:
August 2, 2011
Assignee:
hemoCORM Limited
Inventors:
Roberto Angelo Motterlini, Brian Ernest Mann
Abstract: Metal carbonyls are used to deliver CO having biological activity, for example vasodilatation and inhibition of transplant rejection. The metal of the carbonyl is typically of groups 7 to 10, e.g. Fe and Ru. The carbonyl preferably has one or more ligands other than CO, such as amino acids, to modulate the CO release property and solubility.
Type:
Grant
Filed:
May 14, 2002
Date of Patent:
May 16, 2006
Assignee:
Hemocorm Limited
Inventors:
Roberto Angelo Motterlini, Brian Ernest Mann