Abstract: Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The construct-complex may be formed ex vivo, or a hemoglobin-hepatocyte modifying substance combination may be administered to the patient so that haptoglobin in the mammalian body bonds thereto to form the construct-complex in vivo. Disorders of the liver may be diagnosed and treated using construct-complexes described herein.
Type:
Grant
Filed:
April 30, 1999
Date of Patent:
November 12, 2002
Assignee:
Hemsol Inc.
Inventors:
J. Gordon Adamson, Jolanta Maria Wodzinska, M. S. Celine Moore