Abstract: Disclosed is a centrifugal separation device for removing air bubbles from materials filled into syringes, the device including: a centrifugal separator having a round body, a sealing cover sealably mounted on top of the body, a rotary shaft and a rotary body rotated by the operation of a motor, mounting members coupled to hinge shafts formed on the four faces of the rotary body, the syringes mounted on the mounting members through respective stands, a vacuum pipe and a vacuum releasing pipe connected on the underside of the body, and a vacuum sensor mounted at the inside of the vacuum pipe; a vacuum driving part adapted to absorb the air from the interior of the body through the vacuum pipe to reduce the internal pressure of the body to a given pressure; a sensing part adapted to input the pressure value detected from the vacuum sensor to a controller; a motor driving part adapted to drive the motor to rotate the rotary shaft; and the controller adapted to operate the centrifugal separator, to constantly mai