Patents Assigned to Henry M. Jackson Foundation for Advancement of Military Medicine
  • Cedar virus and methods of use
    Patent number: 10227664
    Abstract: The present invention is directed towards a novel virus, called Cedar Virus, and its methods of use.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: March 12, 2019
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The State of Queensland, Department of Agriculture, Fisheries and Forestry, Commonwealth Scientific and Industrial Research Organization
    Inventors: Linfa Wang, Glenn A. Marsh, Hume Field, Christopher Broder
  • Portable hand pump for evacuation of fluids
    Patent number: 10213532
    Abstract: A manually operable pump for the effective removal of fluids to include blood, blood clots, fluid, and air from a body cavity of a subject is provided. The manually operable pump is adapted to be connect to a range of fluid conduits and is equipped with one-way valves that effectively permit flow of fluid through the pump in only one direction. The sensitivity of the one-way valves is such that when properly positioned, fluid can flow through the valves and out of the pump without manual compression of the pump and with the aid of gravity power alone.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 26, 2019
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Hasan B. Alam, Peter Rhee, Emily Rhee
  • Methods of treating allergies and autoimmune diseases with homogenate of axenic
    Patent number: 10213495
    Abstract: Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans, wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: February 26, 2019
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Edward E. Mitre, Marina Torrero, Belinda Jackson
  • Soluble Forms of Hendra and Nipah Virus G Glycoprotein
    Publication number: 20190031719
    Abstract: This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 31, 2019
    Applicant: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: Christopher C. Broder, Katharine N. Bossart
  • Soluble Forms of Hendra and Nipah Virus F Glycoprotein and Uses Thereof
    Publication number: 20190031721
    Abstract: This invention relates to soluble forms of F glycoprotein from Hendra and Nipah virus and to compositions comprising soluble forms of F glycoprotein from Hendra and Nipah virus. This invention further relates to soluble oligomers of F glycoprotein from Hendra and Nipah virus. This invention also relates to nucleic acids encoding soluble forms of F glycoprotein from Hendra and Nipah virus. This invention also relates to diagnostic and therapeutic methods using the soluble forms of F glycoprotein from Hendra and Nipah virus. Further, this invention relates to antibodies, including neutralizing antibodies, and to vaccines for the prevention, diagnosis and treatment of infection by Hendra and Nipah viruses.
    Type: Application
    Filed: August 6, 2018
    Publication date: January 31, 2019
    Applicant: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: Yee-peng CHAN, Christopher BRODER
  • ANTIGEN-SPECIFIC T CELLS FOR INDUCING IMMUNE TOLERANCE
    Publication number: 20180369350
    Abstract: Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or bi-specific antibodies. The agents and methods can be used to reduce undesirable immune responses.
    Type: Application
    Filed: October 6, 2016
    Publication date: December 27, 2018
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: David W. Scott, Yongchan KIM, Aihong ZHANG
  • Systems and methods for magnetized stent having growth-promoting properties
    Patent number: 10123891
    Abstract: Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residual red blood cells and magnetically nano-treated growth-promoting cells to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 13, 2018
    Assignee: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventor: Teodoro Aclan Tigno, Jr.
  • Antibodies Against F Glycoprotein of Hendra and Nipah Viruses
    Publication number: 20180298081
    Abstract: The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.
    Type: Application
    Filed: April 12, 2018
    Publication date: October 18, 2018
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Yee-Peng CHAN, Christopher C. BRODER
  • Use of specific regulatory T-cells to induce immune tolerance
    Patent number: 10093901
    Abstract: The present invention generally relates to the production of antigen-specific T regulatory cells (Tregs). Such cells can be used in therapy to minimize undesirable immune responses such as those observed in autoimmunity and hemophilia and other diseases as well as in the response to protein therapy for genetic diseases. Methods for producing antigen specific Tregs and conditions for preferential expansion of functionally stable, specific Tregs are also provided.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: October 9, 2018
    Assignee: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: David W. Scott, Yong Chan Kim
  • Truncated HIV envelope proteins (ENV), methods and compositions related thereto
    Patent number: 10081658
    Abstract: The instant application provides methods and related compositions pertaining to novel HIV envelope proteins. In some embodiments, the invention relates to methods and compositions for the preparation, production, and administration of isolated novel HIV envelope nucleic acid and protein sequences suitable, for example, as vaccines against HIV.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 25, 2018
    Assignees: Advanced BioScience Laboratories, Inc., The United States of America as Represented by the Secretary of the Army, The Henry M. Jackson Foundation for the Advancement of Military Medicines, Inc.
    Inventors: Vaniambadi Kalyanaraman, Stephen Whitney, Thomas C. VanCott, Victoria Polonis, Carl Alving, Gary R. Matyas, Mangala Rao, Mary Marovich, Francine McCutchan, Sodsai Tovanabutra, Eric Sanders-Buell
  • Prostate cancer gene expression profiles
    Patent number: 10081842
    Abstract: The present disclosure provides gene expression profiles that are associated with prostate cancer. The gene expression profiles can be used to detect prostate cancer cells in a sample and to distinguish between well differentiated (WD) prostate cancer and poorly differentiated (PD) prostate cancer. Also provided is an array comprising oligonucleotide probes for detecting the unique gene signature associated with WD and/or PD prostate cancer.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: September 25, 2018
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Shiv K. Srivastava, Gyorgy Petrovics
  • Methods of diagnosing or treating prostate cancer using the ERG gene, alone or in combination with other over or under expressed genes in prostate cancer
    Patent number: 10066268
    Abstract: The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: September 4, 2018
    Assignee: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: Gyorgy Petrovics, Shiv Srivastava
  • BIODOSIMETRY PANELS AND METHODS
    Publication number: 20180246100
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 30, 2018
    Applicants: Meso Scale Technologies, LLC., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: William F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • Soluble forms of Hendra and Nipah virus G glycoprotein
    Patent number: 10053495
    Abstract: This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 21, 2018
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Christopher C. Broder, Katharine N. Bossart
  • Electrospun dextran fibers and devices formed therefrom
    Patent number: 10046081
    Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: August 14, 2018
    Assignees: The Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Virginia Commonwealth University
    Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
  • Soluble forms of Hendra and Nipah virus F glycoprotein and uses thereof
    Patent number: 10040825
    Abstract: This invention relates to soluble forms of F glycoprotein from Hendra and Nipah virus and to compositions comprising soluble forms of F glycoprotein from Hendra and Nipah virus. This invention further relates to soluble oligomers of F glycoprotein from Hendra and Nipah virus. This invention also relates to nucleic acids encoding soluble forms of F glycoprotein from Hendra and Nipah virus. This invention also relates to diagnostic and therapeutic methods using the soluble forms of F glycoprotein from Hendra and Nipah virus. Further, this invention relates to antibodies, including neutralizing antibodies, and to vaccines for the prevention, diagnosis and treatment of infection by Hendra and Nipah viruses.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: August 7, 2018
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Yee-peng Chan, Christopher Broder
  • MICRORNA BIOMARKERS FOR TRAUMATIC BRAIN INJURY AND METHODS OF USE THEREOF
    Publication number: 20180216187
    Abstract: The present invention relates to methods of diagnosing traumatic brain injury (TBI) in a subject. The present invention also relates to methods of monitoring the progression of the TBI in a subject.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 2, 2018
    Applicants: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., University of Florida Research Foundation, Inc., Orlando Health, Inc., d/b/a Orlando Regional Medical Center
    Inventors: Radha K. MAHESHWARI, Nagaraja S. BALAKATHIRESAN, Manish BHOMIA, Kevin K. WANG, Linda PAPA
  • INDUCTION OF TUMOR IMMUNITY BY VARIANTS OF FOLATE BINDING PROTEIN
    Publication number: 20180194806
    Abstract: The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.
    Type: Application
    Filed: August 10, 2017
    Publication date: July 12, 2018
    Applicants: Board of Regents, The University of Texas System, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Constantin G. IOANNIDES, George E. PEOPLES
  • Azophenols as ERG Oncogene Inhibitors
    Publication number: 20180169074
    Abstract: Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II) wherein X, X1, X2, X3, X4 and X5, R1 through R4 and R9 are as described.
    Type: Application
    Filed: September 9, 2016
    Publication date: June 21, 2018
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Albert L. DOBI, Clifton L. DALGARD, Shiv K. SRIVASTAVA
  • Antibodies against F glycoprotein of Hendra and Nipah viruses
    Patent number: 9982038
    Abstract: The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and/or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and/or compositions of the invention.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 29, 2018
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Yee-Peng Chan, Christopher C. Broder