Abstract: A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more particularly the sulfuric groups have been reconstituted by reacting a heparin fraction with a mol wt from 2,000 to 5,000 with the sulfotrioxide of a nitrogeneous organic base such as pyridine and trimethylamine. The method of preparation is also disclosed.

Abstract: The invention relates to compounds possessing GABA-like sedative and tranquilizing activity, characterized by being of general formula:X.sub.1 OC--(CH.sub.2).sub.2 --NH--(CH.sub.2).sub.3 --CO--X.sub.2whereX.sub.1 and X.sub.2 are hydroxyl, a C.sub.1 -C.sub.6 alkoxy group or a free or substituted amino group, X.sub.1 being the same as or different from X.sub.2.The invention also relates to processes for their preparation, and composition for pharmaceutical and veterinary use which contains them.

Abstract: Natural heteropolysaccharide, specifically hexuronyl hexosaminoglycane sulfate and, a process to obtain it, which substantially provides for the following steps:(a) hydrolysis of an animal organ with a proteolytic enzyme, in water;(b) precipitation of the hydrolyzed product with a water miscible solvent;(c) solubilization of the precipitate in a solution of a salt of a strong mineral acid;(d) addition of a quaternary ammonium halide to form a soluble complex and a precipitate which is separated;(e) precipitation of such complex by dilution with water;(f) isolation and solubilization of the precipitated complex in a salt solution according to step (c);(g) precipitation of the final product with a water miscible solvent and drying thereof;Such compound is utilized as active principle in pharmaceutical compositions, particularly suitable for the prevention of thrombotic states.

Abstract: Natural heteropolysaccharide, specifically hexuronyl hexosaminoglycane sulfate and, a process to obtain it, which substantially provides for the following steps:(a) hydrolysis of an animal organ with a proteolytic enzyme, in water;(b) precipitation of the hydrolyzed product with a water miscible solvent;(c) solubilization of the precipitate in a solution of a salt of a strong mineral acid;(d) addition of a quaternary ammonium halide to form a soluble complex and a precipitate which is separated;(e) precipitation of such complex by dilution with water;(f) isolation and solubilization of the precipitated complex in a salt solution according to step (c);(g) precipitation of the final product with a water miscible solvent and drying thereof;Such compound is utilized as active principle in pharmaceutical compositions, particularly suitable for the prevention of thrombotic states.