Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
Type:
Grant
Filed:
May 2, 2005
Date of Patent:
April 3, 2012
Assignee:
Hermes Biosciences, Inc.
Inventors:
Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
Abstract: This invention provides antibodies that have improved affinity for the epidermal growth factor receptor (EGFR). In addition, this invention provides microparticles and nanoparticles comprising a plurality of EGFR affinity moieties that are effectively internalized by cells expressing an EGFR.
Type:
Application
Filed:
May 8, 2009
Publication date:
January 14, 2010
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HERMES BIOSCIENCES, INC.
Inventors:
DARYL C. DRUMMOND, DMITRI B. KIRPOTIN, JAMES D. MARKS, YU ZHOU
Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
Type:
Application
Filed:
May 2, 2005
Publication date:
May 24, 2007
Applicant:
Hermes Biosciences, Inc.
Inventors:
Keelung Hong, Daryl Drummond, Dmitri Kirpotin
Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention. The present invention also provides for the methods and kits for the delivery of liposomal compositions to the brain.
Abstract: A liposome composition containing encapsulated compound in stable precipitated form, and a method for producing the composition, are disclosed. The concentration of precipitated compound within the liposomes is severalfold higher than that in the bulk medium, and the concentration of compound within the liposomes is not reduced in the presence of a proton or alkali metal-ion ionophore added to the suspension.